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Protein-coding gene in the species Homo sapiens
Polymerase (DNA-directed), epsilon 4, accessory subunit is a protein that in humans is encoded by the POLE4 gene .[ 5]
POLE4 is a histone -fold protein that interacts with other histone-fold proteins to bind DNA in a sequence-independent manner. These histone-fold protein dimers combine within larger enzymatic complexes for DNA transcription, replication, and packaging.[ 5]
Post SM, Tomkinson AE, Lee EY (2003). "The human checkpoint Rad protein Rad17 is chromatin-associated throughout the cell cycle, localizes to DNA replication sites, and interacts with DNA polymerase epsilon" . Nucleic Acids Res . 31 (19): 5568–75. doi :10.1093/nar/gkg765 . PMC 206465 PMID 14500819 . Li Y, Pursell ZF, Linn S (2000). "Identification and cloning of two histone fold motif-containing subunits of HeLa DNA polymerase epsilon" . J. Biol. Chem . 275 (30): 23247–52. doi :10.1074/jbc.M002548200 PMID 10801849 . Wang YL, Faiola F, Xu M, Pan S, Martinez E (2008). "Human ATAC Is a GCN5/PCAF-containing acetylase complex with a novel NC2-like histone fold module that interacts with the TATA-binding protein" . J. Biol. Chem . 283 (49): 33808–15. doi :10.1074/jbc.M806936200 PMC 2590711 PMID 18838386 .
This article incorporates text from the United States National Library of Medicine , which is in the public domain .
