PIGW

PIGW
Identifiers
Aliases	PIGW, Gwt1, HPMRS5, phosphatidylinositol glycan anchor biosynthesis class W
External IDs	OMIM: 610275; MGI: 1917575; HomoloGene: 6243; GeneCards: PIGW; OMA:PIGW - orthologs
Gene location (Human)
Chr.	Chromosome 17 (human)
End	36,539,310 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	84,771,111 bp
RNA expression pattern
	Top expressed in
	islet of Langerhans; ; endometrium; ; gastrocnemius muscle; ; testicle; ; appendix; ; rectum; ; skeletal muscle tissue; ; mucosa of esophagus; ; lymph node; ; gonad;
	Top expressed in
	epiblast; ; lens; ; quadriceps femoris muscle; ; hepatobiliary system; ; liver; ; muscle of thigh; ; white adipose tissue; ; ileum; ; yolk sac; ; tail of embryo;
	More reference expression data
	n/a
Gene ontology
Molecular function	acyltransferase activity; transferase activity; O-acyltransferase activity; glucosaminyl-phosphatidylinositol O-acyltransferase activity;
Cellular component	membrane; endoplasmic reticulum membrane; integral component of membrane; endoplasmic reticulum;
Biological process	GPI anchor biosynthetic process; GPI anchor metabolic process; protein localization to plasma membrane; preassembly of GPI anchor in ER membrane;
	Sources:Amigo / QuickGO
Orthologs
	284098
	70325
	ENSG00000275600; ENSG00000277161
	ENSMUSG00000045140
	Q7Z7B1
	Q8C398
	NM_178517; NM_001346754; NM_001346755
	NM_001077636; NM_027388; NM_001363112
	NP_001333683; NP_001333684; NP_848612
	NP_001071104; NP_081664; NP_001350041
	Wikidata
View/Edit Human	View/Edit Mouse

Phosphatidylinositol glycan anchor biosynthesis class W is a protein that in humans is encoded by the PIGW gene. ^[5]

Function

Glycosylphosphatidylinositol (GPI) is a complex glycolipid that anchors many proteins to the cell surface. PIGW acts in the third step of GPI biosynthesis and acylates the inositol ring of phosphatidylinositol (Murakami et al., 2003 [PubMed 14517336]).

References

^ ^a ^b ^c ENSG00000277161 GRCh38: Ensembl release 89: ENSG00000275600, ENSG00000277161 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000045140 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: Phosphatidylinositol glycan anchor biosynthesis class W". Retrieved 2016-10-29.

Function

References

Further reading