PHD finger protein 7

PHF7
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1WEQ
Identifiers
Aliases	PHF7, HSPC045, HSPC226, NYD-SP6, PHD finger protein 7
External IDs	MGI: 1919088; HomoloGene: 69217; GeneCards: PHF7; OMA:PHF7 - orthologs
Gene location (Human)
Chr.	Chromosome 3 (human)
End	52,423,641 bp
Gene location (Mouse)
Chr.	Chromosome 14 (mouse)
End	30,973,274 bp
RNA expression pattern
	Top expressed in
	right testis; ; left testis; ; sperm; ; testicle; ; sural nerve; ; Achilles tendon; ; rectum; ; transverse colon; ; gastric mucosa; ; skin of leg;
	Top expressed in
	seminiferous tubule; ; spermatid; ; spermatocyte; ; Paneth cell; ; primary oocyte; ; internal carotid artery; ; fossa; ; external carotid artery; ; corneal stroma; ; zygote;
	More reference expression data
	n/a
Orthologs
	51533
	71838
	ENSG00000010318
	ENSMUSG00000021902
	Q9BWX1
	Q9DAG9
	NM_001278221; NM_016483; NM_173341; NM_001321126; NM_001321127
	NM_027949; NM_001360624; NM_001360625
	NP_001265150; NP_001308055; NP_001308056; NP_057567
	NP_082225; NP_001347553; NP_001347554
	Wikidata
View/Edit Human	View/Edit Mouse

PHD finger protein 7 is a protein that in humans is encoded by the PHF7 gene. ^[5]

Function

Spermatogenesis is a complex process regulated by extracellular and intracellular factors as well as cellular interactions among interstitial cells of the testis, Sertoli cells, and germ cells. This gene is expressed in the testis in Sertoli cells but not germ cells.

The protein encoded by this gene contains plant homeodomain (PHD) finger domains, also known as leukemia associated protein (LAP) domains, believed to be involved in transcriptional regulation. The protein, which localizes to the nucleus of transfected cells, has been implicated in the transcriptional regulation of spermatogenesis. Alternate splicing results in multiple transcript variants of this gene.

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000010318 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000021902 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: PHD finger protein 7". Retrieved 2017-09-05.

Function

References

Further reading