From Wikipedia, the free encyclopedia
Protein-coding gene in the species Homo sapiens
Phosphatase and actin regulator 3 is an enzyme that in humans is encoded by the PHACTR3 gene .[ 5] [ 6]
The protein encoded by this gene is associated with the nuclear scaffold in proliferating cells. It was found to bind to the catalytic subunit of protein phosphatase-1 (PP1) and inhibit PP1 activity, suggesting that this protein may function as a regulatory subunit of PP1. Alternative splicing at this locus results in several transcript variants encoding different isoforms.[ 6]
PHACTR3 has been shown to interact with PPP1CA .[ 7]
^ a b c GRCh38: Ensembl release 89: ENSG00000087495 – Ensembl , May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000027525 – Ensembl , May 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Allen PB, Greenfield AT, Svenningsson P, Haspeslagh DC, Greengard P (May 2004). "Phactrs 1-4: A family of protein phosphatase 1 and actin regulatory proteins" . Proc Natl Acad Sci U S A . 101 (18): 7187–92. Bibcode :2004PNAS..101.7187A . doi :10.1073/pnas.0401673101 PMC 406487 PMID 15107502 . ^ a b "Entrez Gene: PHACTR3 phosphatase and actin regulator 3" .^ Sagara J, Higuchi T, Hattori Y, Moriya M, Sarvotham H, Shima H, Shirato H, Kikuchi K, Taniguchi S (Nov 2003). "Scapinin, a putative protein phosphatase-1 regulatory subunit associated with the nuclear nonchromatin structure" . J. Biol. Chem . 278 (46): 45611–9. doi :10.1074/jbc.M305227200 PMID 12925532 .
Worch S, Fiedler E, Hansmann I, Schlote D (2006). "Genomic organization and expression pattern of scapinin (PHACTR3) in mouse and human". Cytogenet. Genome Res . 115 (1): 23–9. doi :10.1159/000094797 . PMID 16974080 . S2CID 38349132 . Colland F, Jacq X, Trouplin V, Mougin C, Groizeleau C, Hamburger A, Meil A, Wojcik J, Legrain P, Gauthier JM (2004). "Functional proteomics mapping of a human signaling pathway" . Genome Res . 14 (7): 1324–32. doi :10.1101/gr.2334104 . PMC 442148 PMID 15231748 . Sagara J, Higuchi T, Hattori Y, Moriya M, Sarvotham H, Shima H, Shirato H, Kikuchi K, Taniguchi S (2003). "Scapinin, a putative protein phosphatase-1 regulatory subunit associated with the nuclear nonchromatin structure" . J. Biol. Chem . 278 (46): 45611–9. doi :10.1074/jbc.M305227200 PMID 12925532 .
