PFDN2

PFDN2
Identifiers
Aliases	PFDN2, PFD2, prefoldin subunit 2
External IDs	OMIM: 613466; MGI: 1276111; HomoloGene: 7887; GeneCards: PFDN2; OMA:PFDN2 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	161,118,055 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	171,186,822 bp
RNA expression pattern
	Top expressed in
	C1 segment; ; anterior cingulate cortex; ; anterior pituitary; ; ganglionic eminence; ; amygdala; ; gastrocnemius muscle; ; prefrontal cortex; ; Brodmann area 9; ; hypothalamus; ; putamen;
	Top expressed in
	lateral hypothalamus; ; neural layer of retina; ; paraventricular nucleus of hypothalamus; ; central gray substance of midbrain; ; medial vestibular nucleus; ; ventromedial nucleus; ; dorsomedial hypothalamic nucleus; ; cingulate gyrus; ; mammillary body; ; supraoptic nucleus;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	unfolded protein binding; protein folding chaperone activity; protein binding;
Cellular component	cytoplasm; mitochondrion; nucleus; prefoldin complex; cytosol;
Biological process	positive regulation of cytoskeleton organization; protein folding;
	Sources:Amigo / QuickGO
Orthologs
	5202
	18637
	ENSG00000143256
	ENSMUSG00000006412
	Q9UHV9
	O70591
	NM_012394
	NM_011070; NM_001360824; NM_001360825
	NP_036526
	NP_035200; NP_001347753; NP_001347754
	Wikidata
View/Edit Human	View/Edit Mouse

Prefoldin subunit 2 is a protein that in humans is encoded by the PFDN2 gene.^[5]^[6]

This gene encodes a member of the prefoldin beta subunit family. The encoded protein is one of six subunits of prefoldin, a molecular chaperone complex that binds and stabilizes newly synthesized polypeptides, thereby allowing them to fold correctly. The complex, consisting of two alpha and four beta subunits, forms a double beta barrel assembly with six protruding coiled-coils.^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000143256 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000006412 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Eddleston J, Murdoch JN, Copp AJ, Stanier P (Apr 1999). "Physical and transcriptional map of a 3-Mb region of mouse chromosome 1 containing the gene for the neural tube defect mutant loop-tail (Lp)". Genomics. 56 (2): 149–59. doi:10.1006/geno.1998.5701. PMID 10051400.
^ ^a ^b "Entrez Gene: PFDN2 prefoldin subunit 2".

Vainberg IE, Lewis SA, Rommelaere H, et al. (1998). "Prefoldin, a chaperone that delivers unfolded proteins to cytosolic chaperonin". Cell. 93 (5): 863–73. doi:10.1016/S0092-8674(00)81446-4. PMID 9630229. S2CID 16011829.
Hansen WJ, Cowan NJ, Welch WJ (1999). "Prefoldin–Nascent Chain Complexes in the Folding of Cytoskeletal Proteins". J. Cell Biol. 145 (2): 265–77. doi:10.1083/jcb.145.2.265. PMC 2133115. PMID 10209023.
Cowan NJ, Lewis SA (2002). "A chaperone with a hydrophilic surface". Nat. Struct. Biol. 6 (11): 990–1. doi:10.1038/14870. PMID 10542082. S2CID 22081346.
Hu RM, Han ZG, Song HD, et al. (2000). "Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning". Proc. Natl. Acad. Sci. U.S.A. 97 (17): 9543–8. Bibcode:2000PNAS...97.9543H. doi:10.1073/pnas.160270997. PMC 16901. PMID 10931946.
Zhang QH, Ye M, Wu XY, et al. (2001). "Cloning and Functional Analysis of cDNAs with Open Reading Frames for 300 Previously Undefined Genes Expressed in CD34+ Hematopoietic Stem/Progenitor Cells". Genome Res. 10 (10): 1546–60. doi:10.1101/gr.140200. PMC 310934. PMID 11042152.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Gstaiger M, Luke B, Hess D, et al. (2003). "Control of nutrient-sensitive transcription programs by the unconventional prefoldin URI". Science. 302 (5648): 1208–12. Bibcode:2003Sci...302.1208G. doi:10.1126/science.1088401. PMID 14615539. S2CID 26836888.
Simons CT, Staes A, Rommelaere H, et al. (2004). "Selective contribution of eukaryotic prefoldin subunits to actin and tubulin binding". J. Biol. Chem. 279 (6): 4196–203. doi:10.1074/jbc.M306053200. PMID 14634002.
Bouwmeester T, Bauch A, Ruffner H, et al. (2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway". Nat. Cell Biol. 6 (2): 97–105. doi:10.1038/ncb1086. PMID 14743216. S2CID 11683986.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein–protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.

This article on a gene on human chromosome 1 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000143256 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000006412 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10051400-5] Eddleston J, Murdoch JN, Copp AJ, Stanier P (Apr 1999). "Physical and transcriptional map of a 3-Mb region of mouse chromosome 1 containing the gene for the neural tube defect mutant loop-tail (Lp)". Genomics. 56 (2): 149–59. doi:10.1006/geno.1998.5701. PMID 10051400.

[entrez-6] "Entrez Gene: PFDN2 prefoldin subunit 2".

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References

Further reading