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PD 144418

From Wikipedia, the free encyclopedia
PD 144418
Identifiers
  • 1,2,3,6-tetrahydro-5-[3-(4-methylphenyl)-5-isoxazolyl]-1-propylpyridine
CAS Number
ChemSpider
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC18H22N2O
Molar mass282.387 g·mol−1
3D model (JSmol)
  • CCCN1CCC=C(C1)C2=CC(=NO2)C3=CC=C(C=C3)C
  • InChI=1S/C18H22N2O/c1-3-10-20-11-4-5-16(13-20)18-12-17(19-21-18)15-8-6-14(2)7-9-15/h5-9,12H,3-4,10-11,13H2,1-2H3
  • Key:FOQRKFCLRMMKAT-UHFFFAOYSA-N

PD 144418 or 1,2,3,6-tetrahydro-5-[3-(4-methylphenyl)-5-isoxazolyl]-1-propylpyridine is a potent and selective ligand for the sigma-1 receptor, with a reported binding affinity of Ki = 0.08 ± 0.01 nM, and 17,212 times selectivity over the sigma-2 receptor.[1]

References

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  1. ^ Akunne HC, Whetzel SZ, Wiley JN, Corbin AE, Ninteman FW, Tecle H, Pei Y, Pugsley TA, Heffner TG (January 1997). "The pharmacology of the novel and selective sigma ligand, PD 144418". Neuropharmacology. 36 (1): 51–62. doi:10.1016/S0028-3908(96)00161-X. PMID 9144641. S2CID 1356055.