PCYT1B

PCYT1B
Identifiers
Aliases	PCYT1B, CCTB, CTB, phosphate cytidylyltransferase 1, choline, beta, phosphate cytidylyltransferase 1B, choline
External IDs	OMIM: 300948; MGI: 2147987; HomoloGene: 3564; GeneCards: PCYT1B; OMA:PCYT1B - orthologs
Gene location (Human) Chr. X chromosome (human) Band Xp22.11 Start 24,558,087 bp End 24,672,677 bp
Gene location (Mouse) Chr. X chromosome (mouse) Band X|X C3 Start 92,698,469 bp End 92,793,557 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ventricular zone ganglionic eminence prefrontal cortex C1 segment amygdala nucleus accumbens left testis cingulate gyrus anterior cingulate cortex right testis Top expressed in zygote secondary oocyte otolith organ utricle ganglionic eminence dentate gyrus of hippocampal formation granule cell piriform cortex otic vesicle respiratory epithelium olfactory epithelium More reference expression data BioGPS More reference expression data
Gene ontology Molecular function nucleotidyltransferase activity catalytic activity transferase activity choline-phosphate cytidylyltransferase activity phosphatidylcholine binding Cellular component endoplasmic reticulum membrane cytoplasm endoplasmic reticulum Biological process phospholipid biosynthetic process phosphatidylcholine biosynthetic process biosynthesis spermatogenesis ovarian follicle development lipid metabolism CDP-choline pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9468 236899 Ensembl ENSG00000102230 ENSMUSG00000035246 UniProt Q9Y5K3 Q811Q9 RefSeq (mRNA) NM_001163264 NM_001163265 NM_004845 NM_177546 NM_211138 RefSeq (protein) NP_001156736 NP_001156737 NP_004836 NP_808214 NP_997593 Location (UCSC) Chr X: 24.56 – 24.67 Mb Chr X: 92.7 – 92.79 Mb PubMed search
Wikidata
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Choline-phosphate cytidylyltransferase B is an enzyme that in humans is encoded by the PCYT1B gene.

Further reading

• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Ballif BA, Villén J, Beausoleil SA, et al. (2005). "Phosphoproteomic analysis of the developing mouse brain". Mol. Cell. Proteomics. 3 (11): 1093–101. doi:10.1074/mcp.M400085-MCP200. PMID 15345747.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Llorca O, Martín-Benito J, Gómez-Puertas P, et al. (2002). "Analysis of the interaction between the eukaryotic chaperonin CCT and its substrates actin and tubulin". J. Struct. Biol. 135 (2): 205–18. doi:10.1006/jsbi.2001.4359. PMID 11580270.
• McCormack EA, Llorca O, Carrascosa JL, et al. (2002). "Point mutations in a hinge linking the small and large domains of beta-actin result in trapped folding intermediates bound to cytosolic chaperonin CCT". J. Struct. Biol. 135 (2): 198–204. doi:10.1006/jsbi.2001.4385. PMID 11580269.
• Lykidis A, Baburina I, Jackowski S (1999). "Distribution of CTP:phosphocholine cytidylyltransferase (CCT) isoforms. Identification of a new CCTbeta splice variant". J. Biol. Chem. 274 (38): 26992–7001. doi:10.1074/jbc.274.38.26992. PMID 10480912.
• Gubin AN, Njoroge JM, Bouffard GG, Miller JL (1999). "Gene expression in proliferating human erythroid cells". Genomics. 59 (2): 168–77. doi:10.1006/geno.1999.5855. PMID 10409428.