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Protein-coding gene in the species Homo sapiens
Polycomb group RING finger protein 1 , PCGF1, also known as NSPC1 or RNF68 is a RING finger domain protein that in humans is encoded by the PCGF1 gene .[ 5] [ 6]
PCGF1 is a component defining the non-canonical polycomb repressive complex 1.1 (ncPRC1) interacting with RING1A/B , RYBP , BCOR and KDM2B . [ 7] KDM2B sites.[ 8] [ 9] [ 10] RING1B ubiquitin ligase activity that catalyzes the ubiquitination of Lys119 on histone H2A, [ 11] PRC2 and H3K27me3 to effectively initiate a polycomb domain and mediate gene repression. [ 12] [ 13] [ 14]
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