PAOX

PAOX
Identifiers
Aliases	PAOX, PAO, polyamine oxidase (exo-N4-amino), polyamine oxidase
External IDs	OMIM: 615853; MGI: 1916983; HomoloGene: 72096; GeneCards: PAOX; OMA:PAOX - orthologs
Gene location (Human)
Chr.	Chromosome 10 (human)
End	133,391,694 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	139,717,137 bp
RNA expression pattern
	Top expressed in
	sperm; ; left testis; ; right testis; ; testicle; ; gonad; ; right lobe of liver; ; mucosa of transverse colon; ; spleen; ; granulocyte; ; sural nerve;
	Top expressed in
	liver; ; primary oocyte; ; duodenum; ; lip; ; white adipose tissue; ; epiblast; ; esophagus; ; zygote; ; zone of skin; ; bone marrow;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	polyamine oxidase activity; N(1),N(12)-diacetylspermine:oxygen oxidoreductase (3-acetamidopropanal-forming) activity; N1-acetylspermine:oxygen oxidoreductase (3-acetamidopropanal-forming) activity; spermidine:oxygen oxidoreductase (3-aminopropanal-forming) activity; spermine:oxygen oxidoreductase (spermidine-forming) activity; N1-acetylspermidine:oxygen oxidoreductase (3-acetamidopropanal-forming) activity; oxidoreductase activity; signaling receptor binding;
Cellular component	cytoplasm; peroxisome; peroxisomal matrix; cytosol;
Biological process	spermine metabolic process; spermine catabolic process; spermidine catabolic process; positive regulation of spermidine biosynthetic process; polyamine biosynthetic process; putrescine biosynthetic process; polyamine catabolic process; putrescine catabolic process; protein targeting to peroxisome;
	Sources:Amigo / QuickGO
Orthologs
	196743
	212503
	ENSG00000148832
	ENSMUSG00000025464
	Q6QHF9
	Q8C0L6
NM_152911; NM_207125; NM_207126; NM_207127; NM_207128;
	NM_207129
	NM_153783; NM_001346725
	NP_690875; NP_997010; NP_997011
	NP_001333654; NP_722478
	Wikidata
View/Edit Human	View/Edit Mouse

Peroxisomal N(1)-acetyl-spermine/spermidine oxidase is an enzyme that in humans is encoded by the PAOX gene.^[5]^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000148832 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000025464 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Wu T, Yankovskaya V, McIntire WS (Jun 2003). "Cloning, sequencing, and heterologous expression of the murine peroxisomal flavoprotein, N1-acetylated polyamine oxidase". J Biol Chem. 278 (23): 20514–20525. doi:10.1074/jbc.M302149200. PMID 12660232.
^ "Entrez Gene: PAOX polyamine oxidase (exo-N4-amino)".

Järvinen A, Keinänen TA, Grigorenko NA, et al. (2006). "Guide molecule-driven stereospecific degradation of alpha-methylpolyamines by polyamine oxidase". J. Biol. Chem. 281 (8): 4589–4595. doi:10.1074/jbc.M509959200. PMID 16354669.
Pledgie A, Huang Y, Hacker A, et al. (2006). "Spermine oxidase SMO(PAOh1), Not N1-acetylpolyamine oxidase PAO, is the primary source of cytotoxic H2O2 in polyamine analogue-treated human breast cancer cell lines". J. Biol. Chem. 280 (48): 39843–39851. doi:10.1074/jbc.M508177200. PMID 16207710.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–2127. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–45. doi:10.1038/ng1285. PMID 14702039.
Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res. 13 (10): 2265–2270. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Vujcic S, Liang P, Diegelman P, et al. (2003). "Genomic identification and biochemical characterization of the mammalian polyamine oxidase involved in polyamine back-conversion". Biochem. J. 370 (Pt 1): 19–28. doi:10.1042/BJ20021779. PMC 1223169. PMID 12477380.

This article on a gene on human chromosome 10 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000148832 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000025464 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid12660232-5] Wu T, Yankovskaya V, McIntire WS (Jun 2003). "Cloning, sequencing, and heterologous expression of the murine peroxisomal flavoprotein, N1-acetylated polyamine oxidase". J Biol Chem. 278 (23): 20514–20525. doi:10.1074/jbc.M302149200. PMID 12660232.

[entrez-6] "Entrez Gene: PAOX polyamine oxidase (exo-N4-amino)".

[1]

[2]

[3]

[4]

[5]

[6]

References

Further reading