Otu deubiquitinase 5

OTUD5
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3PFY, 3TMO, 3TMP
Identifiers
Aliases	OTUD5, DUBA, OTU deubiquitinase 5, MCAND
External IDs	OMIM: 300713; MGI: 1859615; HomoloGene: 136483; GeneCards: OTUD5; OMA:OTUD5 - orthologs
Gene location (Human) Chr. X chromosome (human) Band Xp11.23 Start 48,922,024 bp End 48,958,386 bp
Gene location (Mouse) Chr. X chromosome (mouse) Band X A1.1|X 3.54 cM Start 7,707,603 bp End 7,742,865 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in skin of arm cardiac muscle tissue of right atrium granulocyte nasal epithelium right hemisphere of cerebellum prefrontal cortex left ovary right ovary spleen right frontal lobe Top expressed in granulocyte Ileal epithelium blood neural layer of retina zygote thymus dentate gyrus of hippocampal formation granule cell tibiofemoral joint superior frontal gyrus ventricular zone More reference expression data BioGPS n/a
Gene ontology Molecular function thiol-dependent deubiquitinase peptidase activity cysteine-type peptidase activity hydrolase activity Lys63-specific deubiquitinase activity deubiquitinase activity Lys48-specific deubiquitinase activity Cellular component cytosol Biological process negative regulation of type I interferon production response to lipopolysaccharide protein K63-linked deubiquitination protein K48-linked deubiquitination proteolysis protein deubiquitination Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 55593 54644 Ensembl ENSG00000068308 ENSMUSG00000031154 UniProt Q96G74 Q3U2S4 RefSeq (mRNA) NM_001136157 NM_001136158 NM_001136159 NM_017602 NM_001290536 NM_001290537 NM_138604 RefSeq (protein) NP_001129629 NP_001129630 NP_001129631 NP_060072 NP_001277465 NP_001277466 NP_613070 Location (UCSC) Chr X: 48.92 – 48.96 Mb Chr X: 7.71 – 7.74 Mb PubMed search
Wikidata
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OTU deubiquitinase 5 is a protein that in humans is encoded by the OTUD5 gene.

Function

This gene encodes a member of the OTU (ovarian tumor) domain-containing cysteine protease superfamily. The OTU domain confers deubiquitinase activity and the encoded protein has been shown to suppress the type I interferon-dependent innate immune response by cleaving the polyubiquitin chain from an essential type I interferon adaptor protein. Cleavage results in disassociation of the adaptor protein from a downstream signaling complex and disruption of the type I interferon signaling cascade. Alternatively spliced transcript variants encoding different isoforms have been described.

Further reading

• Kayagaki N, Phung Q, Chan S, Chaudhari R, Quan C, O'Rourke KM, Eby M, Pietras E, Cheng G, Bazan JF, Zhang Z, Arnott D, Dixit VM (2007). "DUBA: a deubiquitinase that regulates type I interferon production". Science. 318 (5856): 1628–32. Bibcode:2007Sci...318.1628K. doi:10.1126/science.1145918. PMID 17991829. S2CID 46585990.
• Huang OW, Ma X, Yin J, Flinders J, Maurer T, Kayagaki N, Phung Q, Bosanac I, Arnott D, Dixit VM, Hymowitz SG, Starovasnik MA, Cochran AG (2012). "Phosphorylation-dependent activity of the deubiquitinase DUBA". Nat. Struct. Mol. Biol. 19 (2): 171–5. doi:10.1038/nsmb.2206. PMID 22245969. S2CID 33600627.
• Luo J, Lu Z, Lu X, Chen L, Cao J, Zhang S, Ling Y, Zhou X (2013). "OTUD5 regulates p53 stability by deubiquitinating p53". PLOS ONE. 8 (10): e77682. Bibcode:2013PLoSO...877682L. doi:10.1371/journal.pone.0077682. PMC 3797110. PMID 24143256.

External links

• Overview of all the structural information available in the PDB for UniProt: Q96G74 (Human OTU domain-containing protein 5) at the PDBe-KB.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.