Osoresnontrine

Osoresnontrine
Clinical data
Other names	BI-409306
Legal status
Legal status	Investigational;
Identifiers
	IUPAC name 1-(Oxan-4-yl)-6-(pyridin-2-ylmethyl)-5H-pyrazolo[3,4-d]pyrimidin-4-one;
CAS Number	1189767-28-9;
PubChem CID	135908617;
Chemical and physical data
Formula	C16H17N5O2
Molar mass	311.345 g·mol−1

Osoresnontrine (BI-409306) is a phosphodiesterase 9 inhibitor in development for schizophrenia,^[1] attenuated psychosis syndrome,^[2] and Alzheimer's disease.^[3] A preclinical study suggested that it increases memory in rodents.^[4]

References

^ Brown, David; Nakagome, Kazuyuki; Cordes, Joachim; Brenner, Ronald; Gründer, Gerhard; Keefe, Richard S E; Riesenberg, Robert; Walling, David P; Daniels, Kristen; Wang, Lara; McGinniss, Jennifer; Sand, Michael (7 March 2019). "Evaluation of the Efficacy, Safety, and Tolerability of BI 409306, a Novel Phosphodiesterase 9 Inhibitor, in Cognitive Impairment in Schizophrenia: A Randomized, Double-Blind, Placebo-Controlled, Phase II Trial". Schizophrenia Bulletin. 45 (2): 350–359. doi:10.1093/schbul/sby049. PMC 6403090.
^ Keefe, Richard S. E.; Woods, Scott W.; Cannon, Tyrone D.; Ruhrmann, Stephan; Mathalon, Daniel H.; McGuire, Philip; Rosenbrock, Holger; Daniels, Kristen; Cotton, Daniel; Roy, Dooti; Pollentier, Stephane; Sand, Michael (October 2021). "A randomized Phase II trial evaluating efficacy, safety, and tolerability of oral BI 409306 in attenuated psychosis syndrome: Design and rationale". Early Intervention in Psychiatry. 15 (5): 1315–1325. doi:10.1111/eip.13083. ISSN 1751-7885. PMC 8451588.
^ Frölich, Lutz; Wunderlich, Glen; Thamer, Claus; Roehrle, Michael; Garcia, Miguel; Dubois, Bruno (December 2019). "Evaluation of the efficacy, safety and tolerability of orally administered BI 409306, a novel phosphodiesterase type 9 inhibitor, in two randomised controlled phase II studies in patients with prodromal and mild Alzheimer's disease". Alzheimer's Research & Therapy. 11 (1). doi:10.1186/s13195-019-0467-2. PMC 6371616.
^ Rosenbrock, Holger; Giovannini, Riccardo; Schänzle, Gerhard; Koros, Eliza; Runge, Frank; Fuchs, Holger; Marti, Anelise; Reymann, Klaus G.; Schröder, Ulrich H.; Fedele, Ernesto; Dorner-Ciossek, Cornelia (1 December 2019). "The Novel Phosphodiesterase 9A Inhibitor BI 409306 Increases Cyclic Guanosine Monophosphate Levels in the Brain, Promotes Synaptic Plasticity, and Enhances Memory Function in Rodents". Journal of Pharmacology and Experimental Therapeutics. 371 (3): 633–641. doi:10.1124/jpet.119.260059. ISSN 0022-3565.

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[1] Brown, David; Nakagome, Kazuyuki; Cordes, Joachim; Brenner, Ronald; Gründer, Gerhard; Keefe, Richard S E; Riesenberg, Robert; Walling, David P; Daniels, Kristen; Wang, Lara; McGinniss, Jennifer; Sand, Michael (7 March 2019). "Evaluation of the Efficacy, Safety, and Tolerability of BI 409306, a Novel Phosphodiesterase 9 Inhibitor, in Cognitive Impairment in Schizophrenia: A Randomized, Double-Blind, Placebo-Controlled, Phase II Trial". Schizophrenia Bulletin. 45 (2): 350–359. doi:10.1093/schbul/sby049. PMC 6403090.

[2] Keefe, Richard S. E.; Woods, Scott W.; Cannon, Tyrone D.; Ruhrmann, Stephan; Mathalon, Daniel H.; McGuire, Philip; Rosenbrock, Holger; Daniels, Kristen; Cotton, Daniel; Roy, Dooti; Pollentier, Stephane; Sand, Michael (October 2021). "A randomized Phase II trial evaluating efficacy, safety, and tolerability of oral BI 409306 in attenuated psychosis syndrome: Design and rationale". Early Intervention in Psychiatry. 15 (5): 1315–1325. doi:10.1111/eip.13083. ISSN 1751-7885. PMC 8451588.

[3] Frölich, Lutz; Wunderlich, Glen; Thamer, Claus; Roehrle, Michael; Garcia, Miguel; Dubois, Bruno (December 2019). "Evaluation of the efficacy, safety and tolerability of orally administered BI 409306, a novel phosphodiesterase type 9 inhibitor, in two randomised controlled phase II studies in patients with prodromal and mild Alzheimer's disease". Alzheimer's Research & Therapy. 11 (1). doi:10.1186/s13195-019-0467-2. PMC 6371616.

[4] Rosenbrock, Holger; Giovannini, Riccardo; Schänzle, Gerhard; Koros, Eliza; Runge, Frank; Fuchs, Holger; Marti, Anelise; Reymann, Klaus G.; Schröder, Ulrich H.; Fedele, Ernesto; Dorner-Ciossek, Cornelia (1 December 2019). "The Novel Phosphodiesterase 9A Inhibitor BI 409306 Increases Cyclic Guanosine Monophosphate Levels in the Brain, Promotes Synaptic Plasticity, and Enhances Memory Function in Rodents". Journal of Pharmacology and Experimental Therapeutics. 371 (3): 633–641. doi:10.1124/jpet.119.260059. ISSN 0022-3565.

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