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Orlando D. Schärer

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Orlando D. Schärer
Alma materHarvard University, ETH Zürich
Scientific career
FieldsChemical biology, molecular biology, cell biology
InstitutionsCenter for Genomic Integrity,
Institute for Basic Science
UNIST
Stony Brook University
University of Zürich
Thesis A chemical approach toward understanding base excision DNA repair enzymes  (1996)
Doctoral advisorsGregory L. Verdine
Other academic advisorsDuilio Arigoni, Roland Kanaar, Jan Hoeijmakers
WebsiteIBS Center for Genomic Integrity Chemical & Cancer Biology Branch

Orlando David Schärer is a Swiss chemist and biologist researching DNA repair, genomic integrity, and cancer biology.[1] Schärer has taught biology, chemistry and pharmacology at various university levels on three continents. He is a distinguished professor at the Ulsan National Institute of Science and Technology (UNIST) and an associate director of the IBS Center for Genomic Integrity located in Ulsan, South Korea. He leads the three interdisciplinary research teams in the Chemical & Cancer Biology Branch of the center and specifically heads the Cancer Therapeutics Mechanisms Section.[2]

Education

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Majoring in chemistry at ETH Zürich in Switzerland, Schärer received his Diplom (MSc) in 1991 after studying under Professor Duilio Arigoni. He then attended a chemistry PhD program at Harvard and graduated in 1996. As a graduate student in the laboratory of Professor Gregory L. Verdine, Schärer developed chemical approaches to study the DNA glycosylases in base excision repair.[3][4]

Career

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Orlando D. Schärer speaking at Seoul Forum 2023.

Schärer started his career in 1996, as a Human Frontier Science Program postdoctoral fellow in the Department of Cell Biology and Genetics of Erasmus University Rotterdam under Professors Roland Kanaar and Jan Hoeijmakers.[5] During this fellowship, he researched biochemical and genetic aspects of homologous recombination in mammals.[6] Starting in 1999, he was an independent group leader and START Fellow (Swiss Science Foundation Research Professor) in the Institute of Molecular Cancer Research at the University of Zürich.[6] That marked the start of the Schärer lab - researching chemical, biochemical and cell biological approaches to research nucleotide excision repair, interstrand crosslink repair and how DNA repair pathways impact cancer chemotherapy.[7] The last four years of his time in Zürich, he taught biological chemistry as a lecturer at ETH Zürich.

From 2005, he continued his research as a tenured associate professor at Stony Brook in the Departments of Pharmacological Sciences and Chemistry and as a member of the Institute for Chemical Biology and Drug Design.[8][9] During a sabbatical leave in 2011, he was a visiting scientist at the Institute of Molecular Cancer Research in the University of Zürich. Returning from Switzerland, he became a full professor.

In 2017, he became a distinguished professor and the associate director of the IBS Center for Genomic Integrity in UNIST, headed by Myung Kyungjae.[10][11] Located in Ulsan City, Republic of Korea, the new laboratory is divided into three sections; DNA Damage Repair, Molecular Cancer Research, and Cancer Therapeutics Mechanisms.[12]

The Schärer Laboratory is best known for the development of syntheses of DNA interstrand crosslinks[13][14] and other DNA lesions and mechanistic studies of human nucleotide excision repair and interstrand crosslink repair and structure-specific nucleases, such as ERCC1-XPF[15][16] and XPG.[17][18]

Honors and awards

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  • 2016: Excellence in Senior Research Award, Stony Brook University, School of Medicine[19]
  • 2015: Chair, Mammalian DNA Repair Gordon Research Conference[20]
  • 2013: Fanconi Anemia Research Fund Discovery Award
  • 2005: NYSTAR Faculty Development Award, Stony Brook University[21][22]
  • 2004: Grant, Human Frontier Science Program[23]
  • 2001: EMBO Young Investigator Award[24][25]
  • 1999: START fellowship of the Swiss National Science Foundation

See also

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References

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  1. ^ "The synergy between IBS and UNIST propels research forward". Institute for Basic Science. 3 February 2021. Retrieved 4 March 2021.
  2. ^ "Research Groups". Schärer Laboratory. Retrieved 26 July 2019.
  3. ^ Schärer, Orlando D.; Ortholand, Jean-Yves; Ganesan, A.; Ezaz-Nikpay, Khosro; Verdine, Gregory L. (June 1995). "Specific binding of the DNA repair enzyme AlkA to a pyrrolidine-based inhibitor". Journal of the American Chemical Society. 117 (24). American Chemical Society: 6623–6624. doi:10.1021/ja00129a039.
  4. ^ Labahn, Jörg; Schärer, Orlando D.; Long, Alexander; Ezaz-Nikpay, Khosro; Verdine, Gregory L.; Ellenberger, Tom E. (26 July 1996). "Structural basis for the excision repair of alkylation-damaged DNA". Cell. 86 (2). Cell Press: 321–329. doi:10.1016/S0092-8674(00)80103-8. PMID 8706136. S2CID 15333632.
  5. ^ "People: Branch Director". Scharer Laboratory. Retrieved 5 July 2019. ...postdoctoral studies at Erasmus University, Netherlands (Advisors: Profs. Roland Kanaar and Jan Hoeijmakers)...
  6. ^ a b Gillet, Ludovic CJ; Schärer, Orlando D. (27 December 2005). "Molecular Mechanisms of Mammalian Global Genome Nucleotide Excision Repair". Chemical Reviews. 106 (2). American Chemical Society: 253–276. doi:10.1021/cr040483f. PMID 16464005.
  7. ^ "Orlando D. Schärer". LinkedIn. Retrieved 21 June 2019.
  8. ^ "Faculty: ORLANDO D. SCHÄRER, PROFESSOR". Stony Brook University. Retrieved 21 June 2019.
  9. ^ "Faculty / Research: ORLANDO D. SCHÄRER, PHD". Department of Pharmacological Sciences. Stony Brook University School of Medicine. Retrieved 21 June 2019.
  10. ^ "Orlando D., Schaerer 올란도". School of Life Sciences. Ulsan National Institute of Science and Technology. Retrieved 5 July 2019.
  11. ^ "Associate Director". Center for Genomic Integrity. Institute for Basic Science. Retrieved 5 July 2019.
  12. ^ "Research Groups". Scharer Laboratory. Retrieved 5 July 2019.
  13. ^ Angelov, Todor; Guainazzi, Angelo; Schärer, Orlando D. (8 January 2009). "Generation of DNA Interstrand Cross-Links by Post-Synthetic Reductive Amination". Organic Letters. 11 (3). American Chemical Society: 661–664. doi:10.1021/ol802719a. PMC 2635425. PMID 19132933.
  14. ^ Mukherjee, Shivam; Guainazzi, Angelo; Schärer, Orlando D. (2014). "17 June 2014". Nucleic Acids Research. 42 (11): 7429–7435. doi:10.1093/nar/gku328. PMC 4066762. PMID 24782532.
  15. ^ Enzlin, Jacqueline H.; Schärer, Orlando D. (15 April 2002). "The active site of the DNA repair endonuclease XPF–ERCC1 forms a highly conserved nuclease motif". EMBO J. 21 (8): 2045–2053. doi:10.1093/emboj/21.8.2045. PMC 125967. PMID 11953324.
  16. ^ Orelli, Barbara; McClendon, T. Brooke; Tsodikov, Oleg V.; Ellenberger, Tom; Niedernhofer, Laura J.; Schärer, Orlando D. (5 February 2010). "The XPA-binding domain of ERCC1 is required for nucleotide excision repair but not other DNA repair pathways". Journal of Biological Chemistry. 285 (6): 3705–3712. doi:10.1074/jbc.M109.067538. PMC 2823511. PMID 19940136.
  17. ^ Fagbemi, Adebanke F.; Orellia, Barbara; Schärer, Orlando D. (15 July 2011). "Regulation of endonuclease activity in human nucleotide excision repair". DNA Repair. 10 (7): 722–729. doi:10.1016/j.dnarep.2011.04.022. PMC 3139800. PMID 21592868.
  18. ^ Staresincic, Lidija; Fagbemi, Adebanke F.; Enzlin, Jacqueline H.; Gourdin, Audrey M.; Wijgers, Nils; Dunand-Sauthier, Isabelle; Giglia-Mari, Giuseppina; Clarkson, Stuart G.; Vermeulen, Wim; Schärer, Orlando D. (22 April 2009). "Coordination of dual incision and repair synthesis in human nucleotide excision repair". EMBO J. 28 (8): 1111–1120. doi:10.1038/emboj.2009.49. PMC 2683701. PMID 19279666.
  19. ^ "Senior Research Excellence Award Recipients". Renaissance School of Medicine. Stony Brook Medicine. Retrieved 5 July 2019.
  20. ^ "Controlling Traffic on the Streets and at the Crossroads of DNA Repair Pathways". Gordon Research Conference: Mammalian DNA Repair. 8–13 February 2015. Retrieved 26 July 2019. Chairs Orlando D. Schärer
  21. ^ "Awards". Stony Brook University. Retrieved 5 July 2019.
  22. ^ "Awards: Faculty Development Award". Stony Brook University. Retrieved 5 July 2019.
  23. ^ "Awardees". Human Frontier Science Program. Retrieved 30 November 2023.
  24. ^ EMBO EMBC Annual Report 2004 (PDF). European Molecular Biology Organization. 2004. p. 113. Retrieved 5 July 2019.
  25. ^ EMBO EMBC Annual Report 2006: Promoting Excellence in the Molecular Life Sciences (PDF). European Molecular Biology Organization. 2006. p. 115. Retrieved 5 July 2019.
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