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Ohyun Kwon

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Ohyun Kwon
Alma materSeoul National University
Columbia University
Scientific career
InstitutionsUniversity of California, Los Angeles
Harvard University
ThesisStudies in syntheses of the natural products (1998)
Doctoral advisorSamuel J. Danishefsky

Ohyun Kwon is an American chemist who is a professor at the University of California, Los Angeles. Her research considers new methodologies for organic transformations and the development of chiral catalysts.

Early life and education

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Kwon was born in South Korea. She attended the Seoul National University, where she majored in chemistry.[1] She moved to the United States for graduate studies, first joining Columbia University to work in the research group of Samuel J. Danishefsky.[2][3] Her doctorate considered the synthesis of glycolipid Ganglio-N-tetraosylceramide (asialo GM1).[2] Afterwards, Kwon moved to Harvard University as a postdoctoral fellow in the laboratory of Stuart Schreiber,[4] where she worked on a diversity oriented synthesis of macrocycles and multi-cyclic compounds.[2]

Research and career

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Kwon was appointed to the faculty at the University of California, Los Angeles (UCLA) in 2001. Her research considers the development of chiral catalysts, target-oriented synthesis of natural compounds and diversity oriented synthesis of natural-product like molecules.[2] She has explored the activation of the C(sp3)–C(sp2) bond of alkenes that is common in natural products.[2] These can be used for the generation of biologically relevant molecules and total synthesis. Kwon developed organic, phosphine-based catalysts for chemical reactions. She has shown that phosphine-catalysed alleviate annulations can be used to create natural products of medical significance.[2]

Kwon showed that chiral phosphines can be used for asymmetric catalysis, including DIPAMP, DIOP and BINAP.[2][5] These phosphines include stereogenic phosphorus centres, axial chirality and stereogenic carbon centres. Kwon developed a family of phosphines with stereogenic carbon and phosphorus centres that are available from Sigma-Aldrich.[6][7]

Awards and honors

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  • 2018 University of California Center for Accelerated Innovation Technology Development Grant[8]
  • 2019 Novartis Chemistry Lectureship Award[9]
  • 2019 Herbert Newby McCoy Award[10]

Selected publications

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  • Hongchao Guo; Yi Chiao Fan; Zhanhu Sun; Yang Wu; Ohyun Kwon (27 September 2018). "Phosphine Organocatalysis". Chemical Reviews. 118 (20): 10049–10293. doi:10.1021/ACS.CHEMREV.8B00081. ISSN 0009-2665. PMC 6218176. PMID 30260217. Wikidata Q57790695.
  • Xue-Feng Zhu; Jie Lan; Ohyun Kwon (1 April 2003). "An expedient phosphine-catalyzed [4 + 2] annulation: synthesis of highly functionalized tetrahydropyridines". Journal of the American Chemical Society. 125 (16): 4716–4717. doi:10.1021/JA0344009. ISSN 0002-7863. PMID 12696883. Wikidata Q44404323.
  • Zhiming Wang; Xingzhu Xu; Ohyun Kwon (24 March 2014). "Phosphine catalysis of allenes with electrophiles". Chemical Society Reviews. 43 (9): 2927–2940. doi:10.1039/C4CS00054D. ISSN 0306-0012. PMC 4059616. PMID 24663290. Wikidata Q38198956.

References

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  1. ^ Ohyun Kwon. OCLC 4780088793.
  2. ^ a b c d e f g "Kwon, Ohyun | UCLA Chemistry and Biochemistry". www.chemistry.ucla.edu. Retrieved 2021-06-02.
  3. ^ "Directory | UCLA Chemistry and Biochemistry". www.chemistry.ucla.edu. Retrieved 2021-06-02.
  4. ^ Wood, John L. (2020-04-14). Organic Syntheses. John Wiley & Sons. ISBN 978-1-119-70776-9.
  5. ^ Kwon, Ohyun. "Phosphine-Catalyzed Annulations and Their Applications". {{cite journal}}: Cite journal requires |journal= (help)
  6. ^ "Kwon Phosphines: P-Chiral Monodentate Phosphines from Hydroxyproline". Sigma-Aldrich. Retrieved 2021-06-02.
  7. ^ "Kwon Chiral Phosphines - Chiral Catalysts, Ligands, and Reagents". Sigma-Aldrich. Retrieved 2021-06-02.
  8. ^ "UC CAI Technology Development Award | UCLA Chemistry and Biochemistry". www.chemistry.ucla.edu. Retrieved 2021-06-02.
  9. ^ "Kwon group's discovery of new chemical reaction published in Science | UCLA Chemistry and Biochemistry". www.chemistry.ucla.edu. Retrieved 2021-06-02.
  10. ^ "2019-2020 Herbert Newby McCoy Award | UCLA Chemistry and Biochemistry". www.chemistry.ucla.edu. Retrieved 2021-06-02.
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