Jump to content

OTUB2

From Wikipedia, the free encyclopedia
OTUB2
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesOTUB2, C14orf137, OTB2, OTU2, OTU deubiquitinase, ubiquitin aldehyde binding 2
External IDsOMIM: 608338; MGI: 1915399; HomoloGene: 57056; GeneCards: OTUB2; OMA:OTUB2 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_023112

NM_001177841
NM_026580

RefSeq (protein)

NP_075601

NP_001171312
NP_080856

Location (UCSC)Chr 14: 94.03 – 94.05 MbChr 12: 103.35 – 103.37 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Ubiquitin thioesterase OTUB2 is an enzyme that in humans is encoded by the OTUB2 gene.[5][6]

Otubains are deubiquitinating cysteine proteases (DUBs; see MIM 602519) that belong to the ovarian tumor (OTU) protein superfamily. Like other DUBs, otubains cleave proteins precisely at the ubiquitin (UB; see MIM 191339)-protein bond.[6]

References

[edit]
  1. ^ a b c ENSG00000277276 GRCh38: Ensembl release 89: ENSG00000089723, ENSG00000277276Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000021203Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Balakirev MY, Tcherniuk SO, Jaquinod M, Chroboczek J (Apr 2003). "Otubains: a new family of cysteine proteases in the ubiquitin pathway". EMBO Rep. 4 (5): 517–22. doi:10.1038/sj.embor.embor824. PMC 1319179. PMID 12704427.
  6. ^ a b "Entrez Gene: OTUB2 OTU domain, ubiquitin aldehyde binding 2".

Further reading

[edit]