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OSBPL8

From Wikipedia, the free encyclopedia
OSBPL8
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesOSBPL8, MST120, MSTP120, ORP8, OSBP10, oxysterol binding protein like 8
External IDsOMIM: 606736; MGI: 2443807; HomoloGene: 68813; GeneCards: OSBPL8; OMA:OSBPL8 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001003712
NM_020841
NM_001319652
NM_001319653
NM_001319655

NM_001003717
NM_175489

RefSeq (protein)

NP_001003712
NP_001306581
NP_001306582
NP_001306584
NP_065892

NP_001003717
NP_780698

Location (UCSC)Chr 12: 76.35 – 76.56 MbChr 10: 111 – 111.13 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Oxysterol-binding protein-related protein 8 is a protein that in humans is encoded by the OSBPL8 gene.[5][6][7]

This gene encodes a member of the oxysterol-binding protein (OSBP) family, a group of intravenous lipid receptors. Like most members, the encoded protein contains an N-terminal pleckstrin homology domain and a highly conserved C-terminal OSBP-like sterol-binding domain. Two transcript variants encoding different isoforms have been found for this gene.[7]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000091039Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000020189Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Pritchett JW (Mar 1992). "Longitudinal growth and growth-plate activity in the lower extremity". Clin Orthop Relat Res. 275 (275): 274–9. doi:10.1097/00003086-199202000-00041. PMID 1735225.
  6. ^ Yan D, Mayranpaa MI, Wong J, Perttila J, Lehto M, Jauhiainen M, Kovanen PT, Ehnholm C, Brown AJ, Olkkonen VM (Dec 2007). "OSBP-related protein 8 (ORP8) suppresses ABCA1 expression and cholesterol efflux from macrophages". J Biol Chem. 283 (1): 332–40. doi:10.1074/jbc.M705313200. PMID 17991739.
  7. ^ a b "Entrez Gene: OSBPL8 oxysterol binding protein-like 8".

Further reading

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