ODC internal ribosome entry site (IRES)
In molecular biology, the ODC internal ribosome entry site (IRES) is an RNA element present in the 5′ UTR of the mRNA encoding ornithine decarboxylase. It has been suggested that this IRES allows cap-independent translation of ornithine decarboxylase at the G2/M phase of the cell cycle,[1] however there is some doubt about this.[2] Translation from this IRES is activated by the zinc finger protein ZNF9 and by Poly(rC)-binding protein 2 (PCBP2).[3][4] It is also activated in Ras-transformed cells.[5]
See also
[edit]References
[edit]- ^ Pyronnet, S; Pradayrol, L; Sonenberg, N (April 2000). "A cell cycle-dependent internal ribosome entry site". Molecular Cell. 5 (4): 607–616. doi:10.1016/s1097-2765(00)80240-3. PMID 10882097.
- ^ Nishimura, K; Sakuma, A; Yamashita, T; Hirokawa, G; Imataka, H; Kashiwagi, K; Igarashi, K (Dec 7, 2007). "Minor contribution of an internal ribosome entry site in the 5′-UTR of ornithine decarboxylase mRNA on its translation". Biochemical and Biophysical Research Communications. 364 (1): 124–130. doi:10.1016/j.bbrc.2007.09.112. PMID 17927956.
- ^ Gerbasi, VR; Link, AJ (June 2007). "The myotonic dystrophy type 2 protein ZNF9 is part of an ITAF complex that promotes cap-independent translation". Molecular & Cellular Proteomics. 6 (6): 1049–1058. doi:10.1074/mcp.M600384-MCP200. PMID 17327219.
- ^ Sammons, MA; Antons, AK; Bendjennat, M; Udd, B; Krahe, R; Link, AJ (Feb 18, 2010). "ZNF9 activation of IRES-mediated translation of the human ODC mRNA is decreased in myotonic dystrophy type 2". PLOS ONE. 5 (2): e9301. Bibcode:2010PLoSO...5.9301S. doi:10.1371/journal.pone.0009301. PMC 2823779. PMID 20174632.
- ^ Origanti, S; Shantz, LM (May 15, 2007). "Ras transformation of RIE-1 cells activates cap-independent translation of ornithine decarboxylase: regulation by the Raf/MEK/ERK and phosphatidylinositol 3-kinase pathways". Cancer Research. 67 (10): 4834–4842. doi:10.1158/0008-5472.CAN-06-4627. PMID 17510413.
Further reading
[edit]- Pyronnet, S; Pradayrol, L; Sonenberg, N (June 2005). "Alternative splicing facilitates internal ribosome entry on the ornithine decarboxylase mRNA". Cellular and Molecular Life Sciences. 62 (11): 1267–1274. doi:10.1007/s00018-005-5020-8. PMC 11139130. PMID 15905964. S2CID 10814897.