Nucleolar and spindle associated protein 1

NUSAP1
Identifiers
Aliases	NUSAP1, ANKT, BM037, LNP, NUSAP, PRO0310p1, Q0310, SAPL, nucleolar and spindle associated protein 1
External IDs	OMIM: 612818; MGI: 2675669; HomoloGene: 10207; GeneCards: NUSAP1; OMA:NUSAP1 - orthologs
Gene location (Human)
Chr.	Chromosome 15 (human)
End	41,381,050 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	119,481,725 bp
RNA expression pattern
	Top expressed in
	ventricular zone; ; ganglionic eminence; ; bone marrow; ; bone marrow cells; ; gonad; ; appendix; ; lymph node; ; stromal cell of endometrium; ; rectum; ; right adrenal cortex;
	Top expressed in
	genital tubercle; ; fetal liver hematopoietic progenitor cell; ; medial ganglionic eminence; ; blood; ; primary oocyte; ; tibiofemoral joint; ; zygote; ; tail of embryo; ; dermis; ; thymus;
	More reference expression data
	n/a
Gene ontology
Molecular function	microtubule binding; DNA binding; protein binding; RNA binding;
Cellular component	spindle; spindle microtubule; cytoskeleton; microtubule; chromosome; nucleus; nucleolus; cytoplasm; mitotic spindle;
Biological process	cell division; cell cycle; mitotic cytokinesis; mitotic chromosome condensation; establishment of mitotic spindle localization; positive regulation of mitotic nuclear division; microtubule cytoskeleton organization; mitotic sister chromatid segregation;
	Sources:Amigo / QuickGO
Orthologs
	51203
	108907
	ENSG00000137804
	ENSMUSG00000027306
	Q9BXS6
	Q9ERH4
NM_001129897; NM_001243142; NM_001243143; NM_001243144; NM_001301136;
	NM_016359; NM_018454
	NM_001042652; NM_133851
NP_001230071; NP_001230072; NP_001230073; NP_001288065; NP_057443;
	NP_060924
	NP_001036117; NP_598612
	Wikidata
View/Edit Human	View/Edit Mouse

Nucleolar and spindle associated protein 1 is a protein that in humans is encoded by the NUSAP1 gene. ^[5]

Function

NUSAP1 is a nucleolar-spindle-associated protein that plays a role in spindle microtubule organization (Raemaekers et al., 2003 [PubMed 12963707]).[supplied by OMIM, Jun 2009].

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000137804 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000027306 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: Nucleolar and spindle associated protein 1". Retrieved 2018-05-22.

Wadia PP, Coram M, Armstrong RJ, Mindrinos M, Butte AJ, Miklos DB (March 2010). "Antibodies specifically target AML antigen NuSAP1 after allogeneic bone marrow transplantation". Blood. 115 (10): 2077–87. doi:10.1182/blood-2009-03-211375. PMC 2837325. PMID 20053754.
Verbakel W, Carmeliet G, Engelborghs Y (August 2011). "SAP-like domain in nucleolar spindle associated protein mediates mitotic chromosome loading as well as interphase chromatin interaction". Biochem. Biophys. Res. Commun. 411 (4): 732–7. doi:10.1016/j.bbrc.2011.07.015. PMID 21782797.
Chou HY, Wang TH, Lee SC, Hsu PH, Tsai MD, Chang CL, Jeng YM (December 2011). "Phosphorylation of NuSAP by Cdk1 regulates its interaction with microtubules in mitosis". Cell Cycle. 10 (23): 4083–9. doi:10.4161/cc.10.23.18200. PMID 22101338.
Gulzar ZG, McKenney JK, Brooks JD (January 2013). "Increased expression of NuSAP in recurrent prostate cancer is mediated by E2F1". Oncogene. 32 (1): 70–7. doi:10.1038/onc.2012.27. PMC 3360134. PMID 22349817.
Espinosa AM, Alfaro A, Roman-Basaure E, Guardado-Estrada M, Palma Í, Serralde C, Medina I, Juárez E, Bermúdez M, Márquez E, Borges-Ibáñez M, Muñoz-Cortez S, Alcántara-Vázquez A, Alonso P, Curiel-Valdez J, Kofman S, Villegas N, Berumen J (2013). "Mitosis is a source of potential markers for screening and survival and therapeutic targets in cervical cancer". PLOS ONE. 8 (2): e55975. Bibcode:2013PLoSO...855975E. doi:10.1371/journal.pone.0055975. PMC 3566100. PMID 23405241.
Kotian S, Banerjee T, Lockhart A, Huang K, Catalyurek UV, Parvin JD (May 2014). "NUSAP1 influences the DNA damage response by controlling BRCA1 protein levels". Cancer Biol. Ther. 15 (5): 533–43. doi:10.4161/cbt.28019. PMC 4026076. PMID 24521615.
Chen L, Yang L, Qiao F, Hu X, Li S, Yao L, Yang XL, Shao ZM (2015). "High Levels of Nucleolar Spindle-Associated Protein and Reduced Levels of BRCA1 Expression Predict Poor Prognosis in Triple-Negative Breast Cancer". PLOS ONE. 10 (10): e0140572. Bibcode:2015PLoSO..1040572C. doi:10.1371/journal.pone.0140572. PMC 4618922. PMID 26485712.
Okamoto A, Higo M, Shiiba M, Nakashima D, Koyama T, Miyamoto I, Kasama H, Kasamatsu A, Ogawara K, Yokoe H, Tanzawa H, Uzawa K (2015). "Down-Regulation of Nucleolar and Spindle-Associated Protein 1 (NUSAP1) Expression Suppresses Tumor and Cell Proliferation and Enhances Anti-Tumor Effect of Paclitaxel in Oral Squamous Cell Carcinoma". PLOS ONE. 10 (11): e0142252. Bibcode:2015PLoSO..1042252O. doi:10.1371/journal.pone.0142252. PMC 4640814. PMID 26554377.
Li C, Zhang Y, Yang Q, Ye F, Sun SY, Chen ES, Liou YC (January 2016). "NuSAP modulates the dynamics of kinetochore microtubules by attenuating MCAK depolymerisation activity". Sci Rep. 6: 18773. Bibcode:2016NatSR...618773L. doi:10.1038/srep18773. PMC 4702128. PMID 26733216.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This article on a gene on human chromosome 15 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000137804 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000027306 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: Nucleolar and spindle associated protein 1". Retrieved 2018-05-22.

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Function

References

Further reading