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Nicholas Hastie

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Professor
Nicholas Hastie
CBE FRS FRSE
Born
Nicholas Dixon Hastie

(1947-03-29) 29 March 1947 (age 77)[1]
Alma mater
Awards
Scientific career
Institutions
ThesisThe role of the nucleus in influenza virus replication (1973)
Websitewww.ed.ac.uk/profile/professor-nick-hastie

Nicholas Dixon Hastie (born 1947) is a British geneticist, and former Director of the MRC Human Genetics Unit at the University of Edinburgh.[2][3][4][5][6][7][8][9][10][excessive citations]

Education

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He attended Colwyn Bay Grammar school (it became Ysgol Eirias in 1967), where he sang in the choral society.[11]

Hastie was educated at the University of Liverpool and the University of Cambridge.[12]

Awards and honours

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Hastie was elected a Fellow of the Royal Society in 2002. His nomination reads

Distinguished for his original and varied contributions to mammalian developmental genetics, genome organisation and gene expression. His early work established the abundance of messenger RNAs during mouse development, and led to the cloning of several genes that are expressed specifically in the liver. Further studies of the serpin gene family uncovered the first clear example of "accelerated protein evolution". At this time he also identified several novel repetitive elements in the mouse genome. His group was the first to characterise mammalian telomeres, and to demonstrate telomere shortening with age in man. Nick Hastie's current work is focused on human developmental mutations, notably Wilm's tumour and Aniridia. His group demonstrated that aniridia, and the mouse equivalent, smalleye, are caused by mutations in the PAX6 gene. He continues to make incisive contributions to our understanding of the role of WT1, the candidate Wilm's Tumour gene, in development of the kidney and gonad.[13]

Hastie was also a member of the Faculty of 1000.[14]

References

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  1. ^ "HASTIE, Prof. Nicholas Dixon Anne". Who's Who 2014, A & C Black, an imprint of Bloomsbury Publishing plc, 2014; online edn, Oxford University Press.(subscription required)
  2. ^ "PROFESSOR NICHOLAS HASTIE, CBE FRS FRSE". MRC Human Genetics Unit. Archived from the original on 27 August 2016.
  3. ^ "MRC Human Genetics Unit".
  4. ^ Hill, R. E.; Favor, J; Hogan, B. L.; Ton, C. C.; Saunders, G. F.; Hanson, I. M.; Prosser, J; Jordan, T; Hastie, N. D.; Van Heyningen, V (1991). "Mouse small eye results from mutations in a paired-like homeobox-containing gene". Nature. 354 (6354): 522–5. Bibcode:1991Natur.354..522H. doi:10.1038/354522a0. PMID 1684639. S2CID 4317526.
  5. ^ Alan Wright; Nicholas Hastie, eds. (2007). Genes and common diseases. Cambridge University Press. ISBN 978-0-521-83339-4.
  6. ^ Nicholas Hastie's publications indexed by the Scopus bibliographic database. (subscription required)
  7. ^ Hastie, N. D.; Dempster, M.; Dunlop, M. G.; Thompson, A. M.; Green, D. K.; Allshire, R. C. (1990). "Telomere reduction in human colorectal carcinoma and with ageing". Nature. 346 (6287): 866–8. Bibcode:1990Natur.346..866H. doi:10.1038/346866a0. PMID 2392154. S2CID 4258451.
  8. ^ Teslovich, T. M.; Musunuru, K.; Smith, A. V.; Edmondson, A. C.; Stylianou, I. M.; Koseki, M.; Pirruccello, J. P.; Ripatti, S.; Chasman, D. I.; Willer, C. J.; Johansen, C. T.; Fouchier, S. W.; Isaacs, A.; Peloso, G. M.; Barbalic, M.; Ricketts, S. L.; Bis, J. C.; Aulchenko, Y. S.; Thorleifsson, G.; Feitosa, M. F.; Chambers, J.; Orho-Melander, M.; Melander, O.; Johnson, T.; Li, X.; Guo, X.; Li, M.; Shin Cho, Y.; Jin Go, M.; et al. (2010). "Biological, clinical and population relevance of 95 loci for blood lipids". Nature. 466 (7307): 707–13. Bibcode:2010Natur.466..707T. doi:10.1038/nature09270. PMC 3039276. PMID 20686565.
  9. ^ Pritchard-Jones, K; Fleming, S; Davidson, D; Bickmore, W; Porteous, D; Gosden, C; Bard, J; Buckler, A; Pelletier, J; Housman, D; Van Heyningen, Veronica; Hastie, Nicholas (1990). "The candidate Wilms' tumour gene is involved in genitourinary development". Nature. 346 (6280): 194–7. Bibcode:1990Natur.346..194P. doi:10.1038/346194a0. PMID 2164159. S2CID 4350729.
  10. ^ Hastie, N (2012). "Linking genetics with biology in disease research: An interview with Nick Hastie". Disease Models & Mechanisms. 5 (2): 151–4. doi:10.1242/dmm.009605. PMC 3291636. PMID 22382364.
  11. ^ North Wales Weekly News Thursday 29 March 1962, page 15
  12. ^ Hastie, Nicholas (1973). The role of the nucleus in influenza virus replication (PhD thesis). University of Cambridge.
  13. ^ "EC/2002/13: Hastie, Nicholas Dixon". London: The Royal Society. Archived from the original on 11 May 2017.
  14. ^ "Nicholas Hastie | Faculty Member | Faculty Opinions". facultyopinions.com.
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