Neuron derived neurotrophic factor

NDNF
Identifiers
Aliases	NDNF, C4orf31, NORD, neuron-derived neurotrophic factor, neuron derived neurotrophic factor, HH25
External IDs	OMIM: 616506; MGI: 1915419; HomoloGene: 11593; GeneCards: NDNF; OMA:NDNF - orthologs
Gene location (Human)
Chr.	Chromosome 4 (human)
End	121,073,021 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	65,689,310 bp
RNA expression pattern
	Top expressed in
	glomerulus; ; metanephric glomerulus; ; visceral pleura; ; lower lobe of lung; ; periodontal fiber; ; Epithelium of choroid plexus; ; right lung; ; bronchial epithelial cell; ; tibia; ; upper lobe of lung;
	Top expressed in
	calvaria; ; left lung lobe; ; right lung; ; right lung lobe; ; renal corpuscle; ; iris; ; neural layer of retina; ; otolith organ; ; maxillary prominence; ; utricle;
	More reference expression data
	n/a
Gene ontology
Molecular function	glycosaminoglycan binding; heparin binding;
Cellular component	extracellular matrix; intracellular anatomical structure; extracellular region;
Biological process	negative regulation of neuron apoptotic process; negative regulation of endothelial cell apoptotic process; response to ischemia; neuron migration; cellular response to hypoxia; angiogenesis; nervous system development; nitric oxide mediated signal transduction; positive regulation of neuron projection development; positive regulation of cell-substrate adhesion; peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan; extracellular matrix organization; vascular wound healing;
	Sources:Amigo / QuickGO
Orthologs
	79625
	68169
	ENSG00000173376
	ENSMUSG00000049001
	Q8TB73
	Q8C119
	NM_024574
	NM_172399
	NP_078850
	NP_765987
	Wikidata
View/Edit Human	View/Edit Mouse

Neuron derived neurotrophic factor (NDNF) is a secreted protein that, in humans, is located on chromosome 4.^[5] This protein helps in the growth, survival, migration, and differentiation of neurons.^[6] To assist with migration, NDNF shows neuro-repulsive effects on GnRH neurons. Loss of function (LoF) in the NDNF gene has been shown to be a cause of a disease known as congenital hypogonadotropic hypogonadism, which can have associated cleft lip and cleft palate.^[7] A preliminary study has shown that knock-down of ndnf reduces development of the ethmoid plate, which is homologous to the human palate.^[8]^[9]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000173376 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000049001 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "NDNF neuron derived neurotrophic factor [Homo sapiens (human)] - Gene - NCBI". www.ncbi.nlm.nih.gov. Retrieved 2023-05-12.
^ Kuang XL, Zhao XM, Xu HF, Shi YY, Deng JB, Sun GT (October 2010). "Spatio-temporal expression of a novel neuron-derived neurotrophic factor (NDNF) in mouse brains during development". BMC Neuroscience. 11 (1): 137. doi:10.1186/1471-2202-11-137. PMC 2984559. PMID 20969804.
^ Messina A, Pulli K, Santini S, Acierno J, Känsäkoski J, Cassatella D, et al. (January 2020). "Neuron-Derived Neurotrophic Factor Is Mutated in Congenital Hypogonadotropic Hypogonadism". American Journal of Human Genetics. 106 (1): 58–70. doi:10.1016/j.ajhg.2019.12.003. PMC 7042563. PMID 31883645.
^ Swartz ME, Sheehan-Rooney K, Dixon MJ, Eberhart JK (September 2011). "Examination of a palatogenic gene program in zebrafish". Developmental Dynamics. 240 (9): 2204–2220. doi:10.1002/dvdy.22713. PMC 3202344. PMID 22016187.
^ Melvin VS, Feng W, Hernandez-Lagunas L, Artinger KB, Williams T (July 2013). "A morpholino-based screen to identify novel genes involved in craniofacial morphogenesis". Developmental Dynamics. 242 (7): 817–831. doi:10.1002/dvdy.23969. PMC 4027977. PMID 23559552.

References

Further reading