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Naim Akhtar Khan

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Naim Akhtar Khan
Born (1959-06-30) June 30, 1959 (age 65)
India
NationalityFrench
Known forResearch on fat taste receptors and obesity
Scientific career
FieldsPhysiology
InstitutionsUniversity of Burgundy

Naim Akhtar Khan (born June 30, 1959, in India) is a French physiologist and professor at the University of Burgundy, Dijon, France. He leads the research team, Nutrition Physiology & Toxicology (NUTox).[1][2][3][4]

Biography

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Khan obtained his Master's degree in 1979 and completed his PhD at the age of 24. He conducted postdoctoral research at the AIIMS and AMU in India. After a brief research stint in 1987 at the Institut Für Immunologie, Munich, Germany, he moved to Mexico for a postdoctoral fellowship in neuroimmunology at the National Institute for Neurology and Neurosurgery. In 1988, he relocated to Rennes, France, for a second doctorate in neuro-oncology, focusing on the transmembrane transport of polyamines.[5] Khan was awarded his Habilitation à diriger des recherches in 1995 and became a university professor in Dijon in 1997.

Career

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Khan began his teaching career in 1993 as a lecturer in Limoges, France, working on "Fundamental and Comparative Immunology." In 2003, he was appointed as director of the Department of Physiology, Immunology, and Neurosciences at the University of Burgundy. His research led to the publication of significant results in 2014 on the characterization of fat taste receptors, contributing to the development of chemical compounds that mimic fat taste, reducing food intake in obese subjects. These compounds target the CD36 and GPR120 receptors on the tongue.[6][7]

In 2019, Khan filed two European patents in the Innovation category.[8][9] In 2021, he co-founded the company "EktaH",[10][11] focusing on developing new therapeutic solutions to combat obesity.[12][13] In 2022, he joined the Outreach and Engagement Committee of the International Scientific Council,[14] and in 2023, he was appointed a Fellow of the Academy of the IUPS.[15][16]

Research

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Naim Khan's research team, NUTox, has made contributions to understanding the physiological mechanisms of fat taste perception, particularly in relation to obesity. The cornerstone of their research is the concept that while lifestyle modifications such as a low-calorie diet or increased physical activity are traditional interventions for obesity, they often fail in the long term due to humans' genetic, cultural, or socio-economic preference for fatty foods, which provide hedonic pleasure through their taste.

To address this, Khan's team has focused on the study of fat taste receptors, particularly the CD36 and GPR120 receptors located in the taste buds. They have developed several fatty acid analogues known as "lipid decoys."[17][18][19][20] These compounds mimic the taste of fats more intensely than natural dietary fatty acids, thereby binding to the tongue's fat taste receptors and inducing early satiety. This reaction leads to a reduction in the consumption of fat-rich foods and, consequently, body weight in obese models.[21]

In another study, they demonstrated that a GPR120 agonist, TUG-891, can activate the tongue-brain-intestine axis, responsible for the secretion of anorexigenic peptides, which suppress appetite.[22] Furthermore, some of their lipid decoys have shown strong anti-inflammatory activity in various in vitro and in vivo models, adding another layer of therapeutic potential to their research.[23]

Awards and recognition

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Mandates

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  • Professor of Physiology at the University of Burgundy
  • Director of the NUTox team[27]
  • Founding member of the African Society of Physiology and Physopathology[28]
  • Co-founder of EktaH[29][30]

References

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  1. ^ "Naim Akhtar Khan". International Science Council. Retrieved 2024-06-23.
  2. ^ "#07-Menu - CTM" (in French). 2023-08-31. Retrieved 2024-06-23.
  3. ^ Pierre, Jeanne (2021-02-24). "Naim Akhtar Khan : la lutte contre l'obésité". Dijon l'Hebdo (in French). Retrieved 2024-06-23.
  4. ^ "STEP : Science and Technology Exchange Program". step.mstfdn.org. Retrieved 2024-06-24.
  5. ^ Khan, Naim Akhtar (1990-01-01). Étude des mécanismes de transport transmembranaire des polyamines : leur importance au cours de la prolifération cellulaire cancéreuse (These de doctorat thesis). Rennes 1.
  6. ^ Sayed, Amira; Khan, Naim Akhtar (2015-12-01). "Le polymorphisme génétique du CD36, un lipido-récepteur, est-il un facteur prédictif de l'obésité à l'âge adulte ?". Médecine/Sciences (in French). 31 (12): 1072–1074. doi:10.1051/medsci/20153112008. ISSN 0767-0974. PMID 26672657.
  7. ^ "Le plaisir du gras sans les calories ?". Les Echos (in French). 2023-01-27. Retrieved 2024-06-23.
  8. ^ Naim Khan, Sylvain Juge, Aziz Hichami, Jérôme Bayardon, Marie-Laure Louillat-Habermeyer, Baptiste Rugeri (4 December 2019). "EP 3 575 283 A1: LINOLEIC ACID DERIVATIVES, PHARMACEUTICAL COMPOSITION OR FOOD COMPOSITION COMPRISING SAID LINOLEIC ACID DERIVATIVES, AND THEIR USES" (PDF). European Patent Office. Retrieved June 26, 2024.{{cite web}}: CS1 maint: multiple names: authors list (link)
  9. ^ "WIPO - Search International and National Patent Collections". patentscope.wipo.int. Retrieved 2024-06-23.
  10. ^ "La Start-up dijonnaise Ektah et ses recherches prometteuses contre l'obésité et la prise de poids - Université de Bourgogne". www.u-bourgogne.fr (in French). 2022-04-04. Retrieved 2024-06-23.
  11. ^ "Xavier Boidevezi et Naim Khan veulent lutter contre l'obésité". Le Journal du Palais (in French). 2023-02-17. Retrieved 2024-06-23.
  12. ^ "La start-up dijonnaise EktaH rêve de vaincre l'obésité dans le monde - France Bleu". ici par France Bleu et France 3 (in French). 2024-04-08. Retrieved 2024-06-23.
  13. ^ "EktaH veut créer un spray de leurres lipidiques pour lutter contre l'obésité". Les Echos (in French). 2022-02-04. Retrieved 2024-06-23.
  14. ^ "Committee for Outreach and Engagement". International Science Council. Retrieved 2024-06-23.
  15. ^ "Naim Khan nommé "Fellow" de l'Académie des Sciences Physiologiques - L'Institut Agro Dijon". institut-agro-dijon.fr. Retrieved 2024-06-23.
  16. ^ "Naim Khan, nommé comme Fellow de l'Académie des Sciences Physiologiques - Université de Bourgogne". www.u-bourgogne.fr (in French). 2023-06-15. Retrieved 2024-06-23.
  17. ^ Besnard, Philippe; Passilly-Degrace, Patricia; Khan, Naim A. (January 2016). "Taste of Fat: A Sixth Taste Modality?". Physiological Reviews. 96 (1): 151–176. doi:10.1152/physrev.00002.2015. ISSN 1522-1210. PMID 26631596.
  18. ^ Dramane, Gado; Abdoul-Azize, Souleymane; Hichami, Aziz; Vögtle, Timo; Akpona, Simon; Chouabe, Christophe; Sadou, Hassimi; Nieswandt, Bernhard; Besnard, Philippe; Khan, Naim Akhtar (June 2012). "STIM1 regulates calcium signaling in taste bud cells and preference for fat in mice". The Journal of Clinical Investigation. 122 (6): 2267–2282. doi:10.1172/JCI59953. ISSN 1558-8238. PMC 3533500. PMID 22546859.
  19. ^ Plesník, Jiří; Šerý, Omar; Khan, Amira S.; Bielik, Peter; Khan, Naim A. (February 2018). "The rs1527483, but not rs3212018, CD36 polymorphism associates with linoleic acid detection and obesity in Czech young adults". The British Journal of Nutrition. 119 (4): 472–478. doi:10.1017/S0007114517003981. ISSN 1475-2662. PMID 29446339.
  20. ^ Daoudi, Hadjer; Plesník, Jiří; Sayed, Amira; Šerý, Omar; Rouabah, Abdelkader; Rouabah, Leila; Khan, Naim Akhtar (2015-11-04). "Oral Fat Sensing and CD36 Gene Polymorphism in Algerian Lean and Obese Teenagers". Nutrients. 7 (11): 9096–9104. doi:10.3390/nu7115455. ISSN 2072-6643. PMC 4663583. PMID 26556365.
  21. ^ Boutanquoi, Pierre-Marie; Khan, Amira Sayed; Cabeza, Lidia; Jantzen, Lucas; Gautier, Thomas; Yesylevskyy, Semen; Ramseyer, Christophe; Masson, David; Van Waes, Vincent; Hichami, Aziz; Khan, Naim Akhtar (2024-04-10). "A novel fatty acid analogue triggers CD36–GPR120 interaction and exerts anti-inflammatory action in endotoxemia". Cellular and Molecular Life Sciences. 81 (1): 176. doi:10.1007/s00018-024-05207-1. ISSN 1420-682X. PMC 11006773. PMID 38598021.
  22. ^ Murtaza, Babar; Hichami, Aziz; Khan, Amira S.; Shimpukade, Bharat; Ulven, Trond; Ozdener, Mehmet Hakan; Khan, Naim A. (February 2020). "Novel GPR120 agonist TUG891 modulates fat taste perception and preference and activates tongue-brain-gut axis in mice". Journal of Lipid Research. 61 (2): 133–142. doi:10.1194/jlr.RA119000142. ISSN 1539-7262. PMC 6997603. PMID 31806728.
  23. ^ Boutanquoi, Pierre-Marie; Khan, Amira Sayed; Cabeza, Lidia; Jantzen, Lucas; Gautier, Thomas; Yesylevskyy, Semen; Ramseyer, Christophe; Masson, David; Van Waes, Vincent; Hichami, Aziz; Khan, Naim Akhtar (2024-04-10). "A novel fatty acid analogue triggers CD36-GPR120 interaction and exerts anti-inflammatory action in endotoxemia". Cellular and Molecular Life Sciences. 81 (1): 176. doi:10.1007/s00018-024-05207-1. ISSN 1420-9071. PMC 11006773. PMID 38598021.
  24. ^ "Santé. Le prix Robert Naquet remis au professeur Khan". www.bienpublic.com (in French). Retrieved 2024-06-23.
  25. ^ "L'académie de Médecine récompense un professeur de l'Université de Bourgogne pour ses travaux sur l'obésité - France Bleu". ici par France Bleu et France 3 (in French). 2020-11-18. Retrieved 2024-06-23.
  26. ^ "L'Académie de médecine prime Naim Khan, inventeur d'un spray anti-obésité". Le Point (in French). 2020-12-15. Retrieved 2024-06-23.
  27. ^ "L'Académie de Médecine décerne le prix " Alimentation Nutrition " au professeur Naim Khan. - L'Institut Agro Dijon". institut-agro-dijon.fr. Retrieved 2024-06-23.
  28. ^ admin (2021-02-10). "Les Membres de la SA2P". Société Africaine de Physiologie et Physiopathologie (in French). Retrieved 2024-06-23.
  29. ^ Bodkine, Alexandre (2024-03-04). "Vers une révolution française dans la lutte contre l'obésité ?". Entreprendre (in French). Retrieved 2024-06-23.
  30. ^ Tabard, Antonin (2024-02-22). "La start-up EktaH a créé un médicament pour lutter contre l'obésité". ON HEALTH (in French). Retrieved 2024-06-23.
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