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Nagy Habib

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Nagy Habib
Nagy Habib (2021)
Born1952 (age 71–72)
NationalityBritish, Egyptian
OccupationSurgeon
Known forRadio-frequency based surgical devices
Medical career
ProfessionLiver surgeon
InstitutionsImperial College, London
Research

Nagy Habib (born 1952) is a British-Egyptian professor of hepato-biliary surgery at Imperial College, London, and is known for devising radio-frequency based liver resection devices which remove liver tumour with minimal blood loss. His work has also focused on stem cells and gene therapy.

Early life and education

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Nagy Habib was born in Cairo, Egypt, 1952.[1] He trained under both Henri Bismuth [fr] and the transplant surgeon Thomas Starzl.[2]

Career

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His work has focused on stem cells and gene therapy.[3] He led the first clinical trial in the use of oncolytic adenoviruses for the treatment of liver cancer.[4] It was carried out by means of a locally restricted injection into the main blood vessel to the liver.[5][6] The findings were published in 2001.[5][6] It was found to be safe, but the second phase of the trial did not find it effective.[5][6] In 2004, he took stem cells from a person with liver cirrhosis and injected them into their liver artery, resulting in some improvement of liver function.[7]

In 2003 he was appointed professor of hepato-biliary surgery at Imperial College, London.[8] In June 2007 he was appointed pro-rector for Commercial Affairs at Imperial.[4]

Habib developed several radio-frequency (RF) based liver resection devices.[9][10] He devised the Habib RF device using the Habib needle, which has a modified version called the Habib 4X.[10] It removes tumour with minimal blood loss.[10] The procedure has come to be known as 'Habib's resection'.[11]

MiNA Therapeutics, a biotechnology company dealing in small activating RNA technology was co-founded by Habib and his son Robert.[12]

Awards and honours

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He was awarded the Takreem award in December 2012, for his work in liver cancer and radio-frequency based liver resection.[4]

Selected publications

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Articles

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  • Habib, Nagy A.; Sarraf, Catherine E.; Mitry, Ragai R.; Havlík, Roman; Nicholls, Joanna; Kelly, Michael; Vernon, Clare C.; Gueret-Wardle, David; El-Masry, Rashad; Salama, Hosny; Ahmed, Rasha; Michail, Nagy; Edward, Ezzat; Jensen, Steen L. (10 February 2001). "E1B-deleted adenovirus (dl1520) gene therapy for patients with primary and secondary liver tumors". Human Gene Therapy. 12 (3): 219–226. doi:10.1089/10430340150218369. ISSN 1043-0342. PMID 11177559. (Co-author)
  • Habib, Nagy; Salama, Hosny; Abd El Latif Abu Median, Ahmed; Isac Anis, Ilia; Abd Al Aziz, Rasha Ahmed; Sarraf, Catherine; Mitry, Ragai; Havlik, Roman; Seth, Prem; Hartwigsen, Jack; Bhushan, Reva; Nicholls, Joanna; Jensen, Steen (March 2002). "Clinical trial of E1B-deleted adenovirus (dl1520) gene therapy for hepatocellular carcinoma". Cancer Gene Therapy. 9 (3): 254–259. doi:10.1038/sj.cgt.7700431. ISSN 1476-5500. PMID 11896441. S2CID 42290755. (Co-author)
  • Havlik, Roman; Jiao, Long R.; Nicholls, Joanna; Jensen, Steen Lindkaer; Habib, Nagy A. (April 2002). "Gene therapy for liver metastases". Seminars in Oncology. 29 (2): 202–208. doi:10.1053/sonc.2002.31678. ISSN 0093-7754. PMID 11951219. (Co-author)
  • Ferko, A.; Leško, M.; Šubrt, Z.; Melichar, B.; Hoffman, P.; Dvořák, P.; Vacek, Z.; Liao, L.R.; Habib, N.A.; Kočí, J.; Motyčka, P. (December 2006). "A modified radiofrequency-assisted approach to right hemihepatectomy". European Journal of Surgical Oncology (EJSO). 32 (10): 1209–1211. doi:10.1016/j.ejso.2006.07.013. PMID 16950592. (Co-author)

Books

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References

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  1. ^ "Habib Nagy / Curriculum Vitae". www.s466593873.onlinehome.fr. Retrieved 28 November 2021.
  2. ^ "Interview with Nagy Habib". Oligonucleutide Therapeutic Society. 8 January 2019. Archived from the original on 29 November 2021. Retrieved 27 November 2021.
  3. ^ Sugand, Kapil; Hills, Alexander (22 March 2008). "Professor Nagy Habib". British Medical Journal. 336 (7645): s109. doi:10.1136/bmj.39510.543056.CE. ISSN 0959-8138. S2CID 80337462.
  4. ^ a b c "Home - Professor Nagy Habib". www.imperial.ac.uk. Archived from the original on 27 November 2021. Retrieved 27 November 2021.
  5. ^ a b c Doerfler, Walter; Böhm, Petra (2013). Adenoviruses: Model and Vectors in Virus-Host Interactions: Immune System, Oncogenesis, Gene Therapy. Springer. pp. 316–320. ISBN 978-3-662-05599-1.
  6. ^ a b c Avila, M. A.; Berasain, C.; Sangro, B.; Prieto, J. (June 2006). "New therapies for hepatocellular carcinoma". Oncogene. 25 (27): 3866–3884. doi:10.1038/sj.onc.1209550. hdl:10171/27496. ISSN 1476-5594. PMID 6799628. S2CID 8901643.
  7. ^ Nill, Kimball (2005). Glossary of Biotechnology Terms, Fourth Edition (4th ed.). Boca Raton: CRC Press. p. 9. ISBN 0-8493-6609-7.
  8. ^ "Professor Nagy Habib". www.imperial.nhs.uk. Archived from the original on 29 November 2021. Retrieved 28 November 2021.
  9. ^ Krestanova, Alice; Kracmar, Jan; Hlavackova, Milada; Kubicek, Jan; Vavra, Petr; Penhaker, Marek; Ihnat, Petr (2019). "Design and testing of radio frequency instrument RONLINE". In Pietka, Ewa; Badura, Pawel; Kawa, Jacek; Wieclawek, Wojciech (eds.). Information Technology in Biomedicine. Springer. p. 638. ISBN 978-3-030-23761-5.
  10. ^ a b c Kumaran, Vinay (2016). "2. Techniques for transection of the liver". Techniques of Liver Surgery. New Delhi: JP Medical Ltd. p. 15. ISBN 978-93-85891-56-4.
  11. ^ Penhaker, Marek; Vavra, Petr; Hlavackova, Mlada; Kracmar, Jan; Sikora, Tadeusz; Prokop, Lucas (2012). "Linear surgical instrument for bipolar multi electrode radiofrquency ablation". In Madarász, Ladislav; Živčák, Jozef (eds.). Aspects of Computational Intelligence: Theory and Applications: Revised and Selected Papers of the 15th IEEE International Conference on Intelligent Engineering Systems 2011, INES 2011. Springer. p. 308. ISBN 978-3-642-30668-6.
  12. ^ Ralph, Alex (12 May 2021). "Father and son pioneers at MiNA Therapeutics clinch US pharma deal". The Times. Archived from the original on 8 December 2021. Retrieved 8 December 2021.
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