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Nadav Ahituv

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Nadav Ahituv is the Director for the Institute for Human Genetics at the University of California, San Francisco (USCF).[1][2][3] He is also a Professor in the Department of Bioengineering and Therapeutic Sciences and leads the Ahituv Lab at University of California, San Francisco (USCF).[1][4]

Early life and education

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Ahituv received his PhD with distinction in human genetics from Tel-Aviv University, where he worked on hereditary hearing loss.[1][3][2]

Research

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Ahituv developed cis-regulation therapy (CRT) for genetic diseases that are caused due to changes in gene dosage [5][6] and adipose manipulation transplantation (AMT) that engineers fat cells and implants them for therapeutic benefits.[7]

The Ahituv Lab investigates gene regulatory elements and their relationship to human diversity and disease.[4] His lab also focuses on identifying gene regulatory elements and linking nucleotide variation within them to various phenotypes, including morphological differences between species, drug response, and human disease.[8] The lab is one of the developers of massively parallel reporter assays (MPRAs) that allow for high-throughput functional characterization of gene regulatory elements.[9]

Awards and honors

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In 2014, Ahituv received the ASCPT Leon I. Goldberg young investigator award from The American Society for Clinical Pharmacology and Therapeutics.[10][1] In 2024, Ahituv received the Scientific Achievement Award from the The American Society of Human Genetics (ASHG).[11]

References

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  1. ^ a b c d "Nadav Ahituv | UCSF Profiles". profiles.ucsf.edu. Retrieved 2024-03-05.
  2. ^ a b "Nadav Ahituv". Simons Institute for the Theory of Computing. Retrieved 2024-03-05.
  3. ^ a b "Speaker Template". PMWC Precision Medicine World Conference. Retrieved 2024-03-05.
  4. ^ a b "About · Ahituv Lab". Ahituv Lab. Retrieved 2024-03-05.
  5. ^ Matharu, Navneet (2018-12-13). "CRISPR-mediated activation of a promoter or enhancer rescues obesity caused by haploinsufficiency". Science. 363 (6424): eaau0629. doi:10.1126/science.aau0629. ISSN 1095-9203. PMC 6570489. PMID 30545847. S2CID 256746336.
  6. ^ Matharu, Navneet; Ahituv, Nadav (2020-11-01). "Modulating gene regulation to treat genetic disorders". Nature Reviews Drug Discovery. 19 (11): 757–775. doi:10.1038/s41573-020-0083-7. ISSN 1474-1784. PMID 33020616. S2CID 256746336.
  7. ^ Nguyen, Hai (2023-03-29). "Implantation of engineered adipocytes that outcompete tumors for resources suppresses cancer progression". bioRxiv. doi:10.1101/2023.03.28.534564. PMC 10081280. PMID 37034710.
  8. ^ "Nadav Ahituv, PhD". UCSF Institute for Human Genetics. Retrieved 2024-03-05.
  9. ^ Inoue, Fumitaka; Ahituv, Nadav (2015-09-01). "Decoding enhancers using massively parallel reporter assays". Genomics. 106 (3): 159–164. doi:10.1016/j.ygeno.2015.06.005. PMC 4540663. PMID 26072433.
  10. ^ "Nadav Ahituv, PhD | Department of Medicine". medicine.ucsf.edu. Retrieved 2024-03-05.
  11. ^ "2024 ASHG Awards". American Society of Human Genetics. Retrieved 7 October 2024.
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