nadA RNA motif
| nadA | |
|---|---|
 Consensus secondary structure and sequence conservation of nadA RNA | |
| Identifiers | |
| Symbol | nadA |
| Rfam | RF03013 |
| Other data | |
| RNA type | Gene; sRNA |
| SO | SO:0001263 |
| PDB structures | PDBe |
The nadA RNA motif is a conserved RNA structure that was discovered by bioinformatics.[1] The nadA motif is found in Acidobacteriota.
nadA RNAs are usually located upstream of nadA genes, which encode quinolinate synthetase, an enzyme that performs a step in NAD synthesis. However, two nadA RNAs are not upstream of a protein-coding gene. Therefore, it is unclear whether nadA RNAs are likely to function as cis-regulatory elements or as small RNAs. These is also evidence that this motif acts as a riboswitch for the enzyme cofactor NAD+.[2]
References
[edit]- ^ Weinberg Z, Lünse CE, Corbino KA, Ames TD, Nelson JW, Roth A, Perkins KR, Sherlock ME, Breaker RR (October 2017). "Detection of 224 candidate structured RNAs by comparative analysis of specific subsets of intergenic regions". Nucleic Acids Res. 45 (18): 10811–10823. doi:10.1093/nar/gkx699. PMC 5737381. PMID 28977401.
- ^ Malkowski, Sarah N.; Spencer, Tara C. J.; Breaker, Ronald R. (2019-08-29). "Evidence that the nadA Motif is a Bacterial Riboswitch for the Ubiquitous Enzyme Cofactor NAD". RNA. 25 (12): 1616–1627. doi:10.1261/rna.072538.119. ISSN 1469-9001. PMC 6859854. PMID 31467147.