NT5C1A

NT5C1A
Identifiers
Aliases	NT5C1A, CN-I, CN-IA, CN1, CN1A, CNI, 5'-nucleotidase, cytosolic IA
External IDs	OMIM: 610525; MGI: 2155700; HomoloGene: 57173; GeneCards: NT5C1A; OMA:NT5C1A - orthologs
Gene location (Human) Chr. Chromosome 1 (human) Band 1p34.2 Start 39,651,229 bp End 39,672,107 bp
Gene location (Mouse) Chr. Chromosome 4 (mouse) Band 4|4 D2.2 Start 123,095,297 bp End 123,110,068 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in gastrocnemius muscle testicle muscle of thigh apex of heart striated muscle tissue skeletal muscle tissue right atrium right auricle left ventricle cerebellar cortex Top expressed in muscle of thigh skeletal muscle tissue quadriceps femoris muscle adrenal gland cerebellum cerebellar cortex hippocampus proper dentate gyrus of hippocampal formation granule cell circulatory system heart More reference expression data BioGPS n/a
Gene ontology Molecular function nucleotide binding hydrolase activity magnesium ion binding protein binding 5'-nucleotidase activity Cellular component cytoplasm cytosol Biological process nucleoside metabolic process adenosine metabolic process purine nucleotide catabolic process nucleotide metabolic process pyrimidine nucleoside catabolic process dephosphorylation purine nucleoside monophosphate catabolic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 84618 230718 Ensembl ENSG00000116981 ENSMUSG00000054958 UniProt Q9BXI3 A3KFX0 RefSeq (mRNA) NM_032526 NM_001085502 RefSeq (protein) NP_115915 NP_001078971 Location (UCSC) Chr 1: 39.65 – 39.67 Mb Chr 4: 123.1 – 123.11 Mb PubMed search
Wikidata
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5'-nucleotidase, cytosolic IA is a protein that in humans is encoded by the NT5C1A gene.

Function

Cytosolic nucleotidases, such as NT5C1A, dephosphorylate nucleoside monophosphates.

Further reading

• Hunsucker SA, Spychala J, Mitchell BS (2001). "Human cytosolic 5'-nucleotidase I: characterization and role in nucleoside analog resistance". J. Biol. Chem. 276 (13): 10498–504. doi:10.1074/jbc.M011218200. PMID 11133996.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.