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Protein-coding gene in the species Homo sapiens
Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon , also known as NFKBIE , is a protein which in humans is encoded by the NFKBIE gene .[ 5] [ 6]
NFKBIE protein expression is up-regulated following NF-κB activation and during myelopoiesis . NFKBIE is able to inhibit NF-κB-directed transactivation via cytoplasmic retention of REL proteins.[ 6]
NFKB1 or NFKB2 is bound to REL , RELA , or RELB to form the NF-κB transcription factor complex. The NF-κB complex is inhibited by I-kappa-B proteins (NFKBIA or NFKBIB ), which inactivate NF-kappa-B by trapping it in the cytoplasm . Phosphorylation of serine residues on the I-kappa-B proteins by kinases (IKBKA , or IKBKB ) marks them for destruction via the ubiquitination pathway, thereby allowing activation of the NF-kappa-B complex. Activated NF-κB complex translocates into the nucleus and binds DNA at kappa-B-binding motifs such as 5-prime GGGRNNYYCC 3-prime or 5-prime HGGARNYYCC 3-prime (where H is A, C, or T; R is an A or G purine; and Y is a C or T pyrimidine). For some genes, activation requires NF-κB interaction with other transcription factors, such as STAT (see STAT6 ), AP-1 (JUN ), and NFAT (see NFATC1 ).[ 5]
NFKBIE has been shown to interact with NFKB2 ,[ 7] RELA ,[ 7] NFKB1 [ 7] REL .[ 7] [ 8] [ 9]
^ a b c GRCh38: Ensembl release 89: ENSG00000146232 – Ensembl , May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000023947 – Ensembl , May 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ a b "Entrez Gene: NFKBIE nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon" .^ a b Whiteside ST, Epinat JC, Rice NR, Israël A (March 1997). "I kappa B epsilon, a novel member of the I kappa B family, controls RelA and cRel NF-kappa B activity" . EMBO J . 16 (6): 1413–26. doi :10.1093/emboj/16.6.1413 . PMC 1169738 PMID 9135156 . ^ a b c d Li, Z; Nabel G J (October 1997). "A new member of the I kappaB protein family, I kappaB epsilon, inhibits RelA (p65)-mediated NF-kappaB transcription" . Mol. Cell. Biol . 17 (10). United States: 6184–90. doi :10.1128/mcb.17.10.6184 . ISSN 0270-7306 . PMC 232469 PMID 9315679 . ^ Kumar, S; Gélinas C (October 1993). "I kappa B alpha-mediated inhibition of v-Rel DNA binding requires direct interaction with the RXXRXRXXC Rel/kappa B DNA-binding motif" . Proc. Natl. Acad. Sci. U.S.A. 90 (19). United States: 8962–6. Bibcode :1993PNAS...90.8962K . doi :10.1073/pnas.90.19.8962 ISSN 0027-8424 . PMC 47481 PMID 8415639 . ^ Spiecker, M; Darius H; Liao J K (March 2000). "A functional role of I kappa B-epsilon in endothelial cell activation" . J. Immunol . 164 (6). United States: 3316–22. doi :10.4049/jimmunol.164.6.3316 ISSN 0022-1767 . PMID 10706725 .
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