NDOR1

NDOR1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4H2D
Identifiers
Aliases	NDOR1, NR1, bA350O14.9, NADPH dependent diflavin oxidoreductase 1, CIAE1
External IDs	OMIM: 606073; MGI: 1926047; HomoloGene: 7144; GeneCards: NDOR1; OMA:NDOR1 - orthologs
Gene location (Human)
Chr.	Chromosome 9 (human)
End	137,219,361 bp
RNA expression pattern
	Top expressed in
	granulocyte; ; mucosa of transverse colon; ; right lobe of thyroid gland; ; apex of heart; ; right hemisphere of cerebellum; ; spleen; ; right uterine tube; ; left lobe of thyroid gland; ; body of stomach; ; tibial nerve;
	n/a
	More reference expression data
	n/a
Gene ontology
Molecular function	oxidoreductase activity; FMN binding; NADPH-hemoprotein reductase activity; protein binding; flavin adenine dinucleotide binding; NADP binding; oxidoreductase activity, acting on NAD(P)H;
Cellular component	cytoplasm; perinuclear region of cytoplasm; cytosol; intermediate filament cytoskeleton; nucleus;
Biological process	cell death; cellular response to menadione; iron-sulfur cluster assembly;
	Sources:Amigo / QuickGO
Orthologs
	27158
	78797
	ENSG00000188566
	ENSMUSG00000006471
	Q9UHB4
	A2AI05
	NM_001144026; NM_001144027; NM_001144028; NM_014434
	NM_001082476; NM_001252541; NM_001252542; NM_178239
	NP_001137498; NP_001137499; NP_001137500; NP_055249
	NP_001075945; NP_001239470; NP_001239471
	Wikidata
View/Edit Human	View/Edit Mouse

NADPH-dependent diflavin oxidoreductase 1 is an enzyme that in humans is encoded by the NDOR1 gene.^[4]^[5]^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000188566 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Paine MJ, Garner AP, Powell D, Sibbald J, Sales M, Pratt N, Smith T, Tew DG, Wolf CR (Feb 2000). "Cloning and characterization of a novel human dual flavin reductase". J Biol Chem. 275 (2): 1471–8. doi:10.1074/jbc.275.2.1471. PMID 10625700.
^ Finn RD, Basran J, Roitel O, Wolf CR, Munro AW, Paine MJ, Scrutton NS (Mar 2003). "Determination of the redox potentials and electron transfer properties of the FAD- and FMN-binding domains of the human oxidoreductase NR1". Eur J Biochem. 270 (6): 1164–75. doi:10.1046/j.1432-1033.2003.03474.x. PMID 12631275.
^ "Entrez Gene: NDOR1 NADPH dependent diflavin oxidoreductase 1".

Kwasnicka DA, Krakowiak A, Thacker C, et al. (2003). "Coordinate expression of NADPH-dependent flavin reductase, Fre-1, and Hint-related 7meGMP-directed hydrolase, DCS-1". J. Biol. Chem. 278 (40): 39051–8. doi:10.1074/jbc.M306355200. PMC 2556063. PMID 12871939.
Olteanu H, Banerjee R (2003). "Redundancy in the pathway for redox regulation of mammalian methionine synthase: reductive activation by the dual flavoprotein, novel reductase 1". J. Biol. Chem. 278 (40): 38310–4. doi:10.1074/jbc.M306282200. PMID 12871938.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Kornau HC, Schenker LT, Kennedy MB, Seeburg PH (1995). "Domain interaction between NMDA receptor subunits and the postsynaptic density protein PSD-95". Science. 269 (5231): 1737–40. Bibcode:1995Sci...269.1737K. doi:10.1126/science.7569905. PMID 7569905.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000188566 – Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10625700-4] Paine MJ, Garner AP, Powell D, Sibbald J, Sales M, Pratt N, Smith T, Tew DG, Wolf CR (Feb 2000). "Cloning and characterization of a novel human dual flavin reductase". J Biol Chem. 275 (2): 1471–8. doi:10.1074/jbc.275.2.1471. PMID 10625700.

[pmid12631275-5] Finn RD, Basran J, Roitel O, Wolf CR, Munro AW, Paine MJ, Scrutton NS (Mar 2003). "Determination of the redox potentials and electron transfer properties of the FAD- and FMN-binding domains of the human oxidoreductase NR1". Eur J Biochem. 270 (6): 1164–75. doi:10.1046/j.1432-1033.2003.03474.x. PMID 12631275.

[entrez-6] "Entrez Gene: NDOR1 NADPH dependent diflavin oxidoreductase 1".

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References

Further reading