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NAD+ diphosphatase

From Wikipedia, the free encyclopedia
NAD+ diphosphatase
Identifiers
EC no.3.6.1.22
CAS no.37289-33-1
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO
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PMCarticles
PubMedarticles
NCBIproteins

In enzymology, a NAD+ diphosphatase (EC 3.6.1.22) is an enzyme that catalyzes the chemical reaction

NAD+ + H2O AMP + NMN

Thus, the two substrates of this enzyme are NAD+ and H2O, whereas its two products are AMP and NMN.

This enzyme belongs to the family of hydrolases, specifically those acting on acid anhydrides in phosphorus-containing anhydrides. The systematic name of this enzyme class is NAD+ phosphohydrolase. Other names in common use include nicotinamide adenine dinucleotide pyrophosphatase, NADP+ pyrophosphatase, and NADH pyrophosphatase. This enzyme participates in nicotinate and nicotinamide metabolism.

Structural studies

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As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code 2GB5.

References

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  • Anderson BM, Lang CA (1966). "Nicotinamide-adenine dinucleotide pyrophosphatase in the growing and aging mosquito". Biochem. J. 101 (2): 392–6. doi:10.1042/bj1010392. PMC 1270119. PMID 4381708.
  • Nakajima Y, Fukunaga N, Sasaki S, Usami S (1973). "Purification and properties of NADP pyrophosphatase from Proteus vulgaris". Biochim. Biophys. Acta. 293 (1): 242–55. doi:10.1016/0005-2744(73)90397-5. PMID 4405504.