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Myocardin

From Wikipedia, the free encyclopedia
MYOCD
Identifiers
AliasesMYOCD, MYCD, myocardin, MGBL
External IDsOMIM: 606127; MGI: 2137495; HomoloGene: 17043; GeneCards: MYOCD; OMA:MYOCD - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001146312
NM_001146313
NM_153604
NM_001378306

NM_145136
NM_146386

RefSeq (protein)

NP_001139784
NP_705832
NP_001365235

NP_660118
NP_666498

Location (UCSC)Chr 17: 12.67 – 12.77 MbChr 11: 65.07 – 65.16 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Myocardin is a protein that in humans is encoded by the MYOCD gene.[5][6][7]

Myocardin is a smooth muscle and cardiac muscle-specific transcriptional coactivator of serum response factor. When expressed ectopically in nonmuscle cells, myocardin can induce smooth muscle differentiation by its association with serum response factor (SRF; MIM 600589).[supplied by OMIM][7]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000141052Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000020542Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Wang D, Chang PS, Wang Z, Sutherland L, Richardson JA, Small E, Krieg PA, Olson EN (Jul 2001). "Activation of cardiac gene expression by myocardin, a transcriptional cofactor for serum response factor". Cell. 105 (7): 851–62. doi:10.1016/S0092-8674(01)00404-4. PMID 11439182. S2CID 3762021.
  6. ^ Wang DZ, Li S, Hockemeyer D, Sutherland L, Wang Z, Schratt G, Richardson JA, Nordheim A, Olson EN (Nov 2002). "Potentiation of serum response factor activity by a family of myocardin-related transcription factors". Proc Natl Acad Sci U S A. 99 (23): 14855–60. Bibcode:2002PNAS...9914855W. doi:10.1073/pnas.222561499. PMC 137508. PMID 12397177.
  7. ^ a b "Entrez Gene: MYOCD myocardin".

Further reading

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