Mycobacterium obuense
| Mycobacterium obuense | |
|---|---|
Scientific classification 
| |
| Domain: | Bacteria |
| Phylum: | Actinomycetota |
| Class: | Actinomycetia |
| Order: | Mycobacteriales |
| Family: | Mycobacteriaceae |
| Genus: | Mycobacterium |
| Species: | M. obuense
|
| Binomial name | |
| Mycobacterium obuense (ex Tsukamura and Mizuno 1971) Tsukamura and Mizuno 1981
| |
Mycobacterium obuense is a species of soil-dwelling scotochromogenic Mycobacterium.[1] The cell wall of M. obuense contains 1-tetradecanol, 2-octadecanol, and 2-eicosanol,[2] and triacylated lipoproteins.
Use in immunomodulatory therapy
[edit]Preparations of heat-killed Mycobacterium obuense (such as IMM-101) are immunomodulatory and have been used to direct the immune response in the treatment of cancers - notably pancreatic cancer and malignant melanoma. Recent trials have been directed towards the treatment of colorectal cancer.[3] It has been shown that human myeloid dendritic cells, (antigen-presenting cells that serve as a bridge linking the adaptive and innate immune system), can detect mycobacterial triacylated lipoproteins via TLR2 and TLR1.[4]
References
[edit]- ^ Tsukamura, M; Mizuno, S (October 1971). "Mycobacterium obuense, a rapidly growing scotochromogenic mycobacterium capable of forming a black product from p-aminosalicylate and salicylate". J. Gen. Microbiol. 68 (2): 129–34. doi:10.1099/00221287-68-2-129. PMID 5136244.
- ^ P.L. Valero-Guillén, F. Martín-Luengo (1986). "1-Tetradecanol, a new alcohol found in the cell wall of some rapidly growing chromogenic mycobacteria". FEMS Microbiology Letters. 35: 59–63. doi:10.1111/j.1574-6968.1986.tb01499.x.
- ^ "Clinical trials - new cancer treatment". Thelondonclinic.co.uk. 2012-04-25. Archived from the original on 2012-09-20. Retrieved 2012-10-04.
- ^ S. Bazzi, H. Modjtahedi, S. Mudan, M. Achkar, C., G.M. Bahr (2017). "Immunomodulatory effects of heat-killed Mycobacterium obuense on human blood dendritic cells". Innate Immunity. 23 (7): 592–605. doi:10.1177/1753425917727838. PMID 28853313. S2CID 206788250.
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External links
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