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Moriel Zelikowsky

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Moriel Zelikowsky
NationalityAmerican
Alma materUniversity of California, Los Angeles
Known forNeural circuits underlying fear and stress
AwardsNARSAD Young Investigator Award, LOREAL for Women in Science Award, Sloan 2020 Award in Neuroscience
Scientific career
InstitutionsUniversity of Utah School of Medicine
Websitehttps://www.zelikowskylab.com/

Moriel Zelikowsky is a neuroscientist at University of Utah School of Medicine. Her laboratory studies the brain circuits and neural mechanisms underlying stress, fear, and social behavior. Her previous work includes fear and the hippocampus, and the role of neuropeptide Tac2 in social isolation.

Early life and education

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Zelikowsky was raised in Los Angeles and earned her bachelor's degree in Philosophy in 2006 from UCLA.[1] Originally, Zelikowsky started out as a film major until she took a few metaphysics classes. After deciding she was more interested in tangible answers to questions such as "what is the brain?" or "how do we think?" that she asked during philosophy classes, she started taking neuropsychiatry classes and applied to P.h.D programs in Psychology.[2] She joined the laboratory of Dr. Michael Fanselow at UCLA, which studies behavioral neuroscience, specifically fear learning and how fear memories are stored in the brain.[3] Her thesis work showed that a dynamic circuit composed of the amygdala, hippocampus, and prefrontal cortex contributes to fear learning and extinction in a context-sensitive manner.[4] Her work was published in the Journal of Neuroscience and was awarded the New York Academy of Sciences Cattell Award[5] and the Gengerelli Distinguished Dissertation Award.[6] She received her P.h.D in 2012.

Career and research

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After receiving her P.h.D, Zelikowsky worked a postdoctoral fellow in the lab of Dr. David J. Anderson in the Department of Biology and Biological Engineering at Caltech.[6] Her work investigated how trauma and chronic stress are represented in the brain, and how neurons in these regions affect the impact of future stress on emotions and social behavior. Zelikowsky and colleagues in the Anderson lab identified a population of neuromodulators involved in stress regulation.[7] In an interview with L'Oréal USA For Women in Science, Zelikowsky explained "The brain undergoes significant change following an intense emotional event, and these alterations in neural processing and dynamics give rise to maladaptive behaviors. It is my hope that my research will contribute to a global shift towards increased cellular precision in our approach towards the treatment of mental health disorders".[8] A significant portion of this research focused specifically on social isolation and Tac2 and its influence on behavior.[9] As a postdoctoral fellow, Zelikowsky was supported by multiple awards and fellowships, including the National Science Foundation, a NARSAD Young Investigator Award,[10] a LOREAL for Women in Science Award,[8] and a NIMH K99/R00 Pathway to Independence Award.[11][12][6]

In the fall of 2019, Zelikowsky started her own lab at the University of Utah School of Medicine as an Assistant Professor in the Department of Neurobiology and Anatomy. Research projects in the lab include prolonged social isolation, post traumatic stress disorder, the intersection or memory and social behavior, and stress and mating.[13] Zelikowsky was recently awarded a 2020 Sloan Research Fellowship in recognition of "creativity, leadership, and achievements in research".[14]

In addition to her research, Zelikowsky also founded a group called Women in Learning which aims to provide a way for students and postdoctoral fellows studying learning, behavior, memory, and the broader field of neuroscience to find support and guidance on the promotion of female researchers from notable women already established in the field.[15]

Publications

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The following are some of Zelikowsky's publications:[16]

  1. Zelikowsky M, Ding K, Anderson DJ. Neuropeptidergic control of an internal brain state produced by prolonged social isolation stress. Cold Spring Harb Symp Quant Biol (2019). doi: 10.1101/sqb.2018.83.038109[17]
  2. Zelikowsky M, Hui M, Karigo T, Yang B, Blanco M, Beadle K, Gradinaru V, Deverman BE, Anderson DJ. The neuropeptide Tac2 controls a distributed brain state induced by chronic social isolation stress. Cell (2018). doi: 10.1016/j.cell.2018.03.037[18]
  3. Remedios R*, Kennedy A*, Zelikowsky M, Grewe B, Schnitzer M, Anderson DJ. Social behaviour shapes hypothalamic neural ensemble representations of conspecific sex. Nature 550, 388–392 (2017). doi: 10.1038/nature23885[19]
  4. Kunwar P, Zelikowsky M, Remedios R, Cai H, Yilmaz M, Meister M, Anderson DJ. Ventromedial hypothalamic neurons control a defensive emotion state. eLife 4 (2015). doi: 10.7554/eLife.06633[20]
  5. Hong W, Kennedy A, Burgos-Artizzu XP, Zelikowsky M, Navonne SG, Perona P, Anderson DJ. Automated Measurement of Mouse Social Behaviors Using Depth Sensing, Video Tracking, and Machine Learning. Proceedings of the National Academy of Sciences 112, E5351-5360 (2015). doi: 10.1073/pnas.1515982112[21]
  6. Zelikowsky M, Chawla M, Hersman S, Barnes CA, Fanselow MS. Neuronal ensembles in amygdala, hippocampus and prefrontal cortex track differential components of contextual fear. Journal of Neuroscience 34, 8462-8466 (2014). doi: 10.1523/JNEUROSCI.3624-13.2014[4]
  7. Fanselow MS, Zelikowsky M, Perusini J, Rodriguez-Barrera V,  & Hersman S. Isomorphisms between psychological processes and neural mechanisms: from stimulus elements to genetic markers of activity. Neurobiology of Learning and Memory 108, 5-13 (2014). doi: 10.1016/j.nlm.2013.10.021[22]
  8. Zelikowsky M, Bissiere S, Hast TA, Bennett RZ, Abdipranato A, Vissel B & Fanselow MS. Prefrontal microcircuit underlies contextual learning after hippocampal loss. Proceedings of the National Academy of Sciences 110, 9938-9943 (2013). doi: 10.1073/pnas.1301691110[23]
  9. Zelikowsky M, Hast TA, Bennett RZ, Merjanian M, Nocera, NA, Ponnusamy R, Fanselow MS. Cholinergic blockade frees fear extinction from its contextual dependency. Biological Psychiatry 73, 345-352 (2013). doi: 10.1016/j.biopsych.2012.08.006[24]
  10. Zelikowsky M, Bissiere S, Fanselow, MS. Contextual fear memories formed in the absence of the dorsal hippocampus decay across time. Journal of Neuroscience 32, 3393-3397 (2012). doi: 10.1523/JNEUROSCI.4339-11.2012[25]
  11. Halladay L, Zelikowsky M, Blair HT, Fanselow MS. Reinstatement of extinguished fear by an unextinguished conditional stimulus. Frontiers in Behavioral Neuroscience 6, 18 (2012). doi: 10.3389/fnbeh.2012.00018[26]
  12. Zelikowsky M, Pham, D, Fanselow, MS. Temporal factors control hippocampal contribution to fear renewal. Hippocampus 22, 1096-1106 (2012). doi: 10.1002/hipo.20954[27]
  13. Bissiere S, Zelikowsky M, Ponnusamy R, Jacobs NS, Blair HT, Fanselow MS. Electrical synapses control hippocampal contributions to fear learning and memory. Science 331, 87-91 (2011). doi: 10.1126/science.1193785[28]
  14. Krasne, F, Fanselow, MS, Zelikowsky M. Design of a neurally plausible fear learning model. Frontiers in Behavioral Neuroscience 5, 41 (2011). doi: 10.3389/fnbeh.2011.00041[29]
  15. Zelikowsky M & Fanselow MS. Conditional analgesia, negative feedback & error correction. Associative Learning and Conditioning: Human and Animal Applications (eds Schachtman TR & Reilly SS). Oxford University Press (2011). doi: 10.1093/acprof:oso/9780199735969.003.0094[30]
  16. Zelikowsky M & Fanselow MS. Opioid regulation of Pavlovian overshadowing in fear conditioning. Behavioral Neuroscience 124, 510-519 (2010). doi: 10.1037/a0020083[31]
  17. Craske MG, Kircanski K, Zelikowsky M, Mystkowski J, Chowdhury N, Baker A. Optimizing inhibitory learning during exposure therapy.  Behavioral Research and Therapy 46, 5-27 (2008). doi: 10.1016/j.brat.2007.10.003[32]

Awards and honors

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The following are awards and honors received by Zelikowsky:[6]

  • 2011 - American Psychological Association Fellowship[33]
  • 2012 - Gengerelli Distinguished Dissertation Award (UCLA)[34]
  • 2013 - New York Academy of Sciences Cattell Award[5]
  • 2013 - National Science Foundation Fellowship[35]
  • 2015 - NARSAD Young Investigator Award[10]
  • 2016 - LOREAL for Women in Science Award[8]
  • 2016 - NIMH K99/R00 Pathway to Independence Award[11][12]
  • 2020 - Sloan Research Fellowship[14]
  • 2020 - Whitehall Foundation Research Award[36]
  • 2020 - Klingenstein-Simmons Fellowship Awards in Neuroscience[37]

References

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  1. ^ "Meet Moriel Zelikowsky". passerbuys. Retrieved 2020-03-07.
  2. ^ Cahn, Megan (2016-12-06). "My Beauty Uniform: Moriel Zelikowsky". A Cup of Jo. Retrieved 2020-03-07.
  3. ^ "Faculty Page | UCLA Psychology Department". www.psych.ucla.edu. Retrieved 2020-03-07.
  4. ^ a b Zelikowsky, Moriel; Hersman, Sarah; Chawla, Monica K.; Barnes, Carol A.; Fanselow, Michael S. (2014-06-18). "Neuronal Ensembles in Amygdala, Hippocampus, and Prefrontal Cortex Track Differential Components of Contextual Fear". The Journal of Neuroscience. 34 (25): 8462–8466. doi:10.1523/JNEUROSCI.3624-13.2014. ISSN 0270-6474. PMC 4061389. PMID 24948801.
  5. ^ a b "Alum Moriel Zelikowksy wins Cattell Award! | UCLA Psychology Department". www.psych.ucla.edu. Retrieved 2020-03-07.
  6. ^ a b c d "People". Zelikowsky Lab. Retrieved 2020-03-07.
  7. ^ Flint, Jonathan; Greenspan, Ralph J.; Kendler, Kenneth S. (2020-01-23). How Genes Influence Behavior 2e. Oxford University Press. ISBN 978-0-19-871687-7.
  8. ^ a b c "Postdoc Named L'Oréal USA For Women in Science Fellow". www.caltech.edu. 26 September 2016. Retrieved 2020-03-07.
  9. ^ Zelikowsky, Moriel; Hui, May; Karigo, Tomomi; Choe, Andrea; Yang, Bin; Blanco, Mario; Beadle, Keith; Gradinaru, Viviana; Deverman, Benjamin E.; Anderson, David J. (2018-05-17). "The neuropeptide Tac2 controls a distributed brain state induced by chronic social isolation stress". Cell. 173 (5): 1265–1279.e19. doi:10.1016/j.cell.2018.03.037. ISSN 0092-8674. PMC 5967263. PMID 29775595.
  10. ^ a b "2015 Young Investigator Grant Program" (PDF). p. 14.
  11. ^ a b "RePORT ⟩ RePORTER". reporter.nih.gov. Retrieved 2021-08-03.
  12. ^ a b "RePORT ⟩ RePORTER". reporter.nih.gov. Retrieved 2021-08-03.
  13. ^ "Research". Zelikowsky Lab. Retrieved 2020-03-07.
  14. ^ a b ""A researcher to watch": Neurobiologist Moriel Zelikowsky Awarded Sloan Fellowship". healthcare.utah.edu. Retrieved 2020-03-07.
  15. ^ "Women in Learning". Women in Learning. Retrieved 2020-03-07.
  16. ^ "Publications". Zelikowsky Lab. Retrieved 2020-03-07.
  17. ^ Zelikowsky, Moriel; Ding, Keke; Anderson, David J. (2018). "Neuropeptidergic Control of an Internal Brain State Produced by Prolonged Social Isolation Stress". Cold Spring Harbor Symposia on Quantitative Biology. 83: 97–103. doi:10.1101/sqb.2018.83.038109. ISSN 1943-4456. PMID 30948452.
  18. ^ Zelikowsky, Moriel; Hui, May; Karigo, Tomomi; Choe, Andrea; Yang, Bin; Blanco, Mario R.; Beadle, Keith; Gradinaru, Viviana; Deverman, Benjamin E.; Anderson, David J. (17 May 2018). "The Neuropeptide Tac2 Controls a Distributed Brain State Induced by Chronic Social Isolation Stress". Cell. 173 (5): 1265–1279.e19. doi:10.1016/j.cell.2018.03.037. ISSN 1097-4172. PMC 5967263. PMID 29775595.
  19. ^ Remedios, Ryan; Kennedy, Ann; Zelikowsky, Moriel; Grewe, Benjamin F.; Schnitzer, Mark J.; Anderson, David J. (18 October 2017). "Social behaviour shapes hypothalamic neural ensemble representations of conspecific sex". Nature. 550 (7676): 388–392. Bibcode:2017Natur.550..388R. doi:10.1038/nature23885. ISSN 1476-4687. PMC 5674977. PMID 29052632.
  20. ^ Kunwar, Prabhat S; Zelikowsky, Moriel; Remedios, Ryan; Cai, Haijiang; Yilmaz, Melis; Meister, Markus; Anderson, David J (2015-03-06). Palmiter, Richard D (ed.). "Ventromedial hypothalamic neurons control a defensive emotion state". eLife. 4: e06633. doi:10.7554/eLife.06633. ISSN 2050-084X. PMC 4379496. PMID 25748136.
  21. ^ Hong, Weizhe; Kennedy, Ann; Burgos-Artizzu, Xavier P.; Zelikowsky, Moriel; Navonne, Santiago G.; Perona, Pietro; Anderson, David J. (2015-09-22). "Automated measurement of mouse social behaviors using depth sensing, video tracking, and machine learning". Proceedings of the National Academy of Sciences of the United States of America. 112 (38): E5351–5360. Bibcode:2015PNAS..112E5351H. doi:10.1073/pnas.1515982112. ISSN 1091-6490. PMC 4586844. PMID 26354123.
  22. ^ Fanselow, Michael S.; Zelikowsky, Moriel; Perusini, Jennifer; Barrera, Vanessa Rodriguez; Hersman, Sarah (February 2014). "Isomorphisms between Psychological Processes and Neural Mechanisms: From Stimulus elements to genetic markers of activity". Neurobiology of Learning and Memory. 108: 5–13. doi:10.1016/j.nlm.2013.10.021. ISSN 1074-7427. PMC 3946164. PMID 24216140.
  23. ^ Zelikowsky, Moriel; Bissiere, Stephanie; Hast, Timothy A.; Bennett, Rebecca Z.; Abdipranoto, Andrea; Vissel, Bryce; Fanselow, Michael S. (2013-06-11). "Prefrontal microcircuit underlies contextual learning after hippocampal loss". Proceedings of the National Academy of Sciences of the United States of America. 110 (24): 9938–9943. Bibcode:2013PNAS..110.9938Z. doi:10.1073/pnas.1301691110. ISSN 1091-6490. PMC 3683762. PMID 23676273.
  24. ^ Zelikowsky, Moriel; Hast, Timothy A.; Bennett, Rebecca Z.; Merjanian, Michael; Nocera, Nathaniel A.; Ponnusamy, Ravikumar; Fanselow, Michael S. (2013-02-15). "Cholinergic blockade frees fear extinction from its contextual dependency". Biological Psychiatry. 73 (4): 345–352. doi:10.1016/j.biopsych.2012.08.006. ISSN 0006-3223. PMC 3525775. PMID 22981655.
  25. ^ Zelikowsky, Moriel; Bissiere, Stephanie; Fanselow, Michael S. (2012-03-07). "Contextual Fear Memories Formed in the Absence of the Dorsal Hippocampus Decay Across Time". The Journal of Neuroscience. 32 (10): 3393–3397. doi:10.1523/JNEUROSCI.4339-11.2012. ISSN 0270-6474. PMC 3306617. PMID 22399761.
  26. ^ Halladay, Lindsay R.; Zelikowsky, Moriel; Blair, Hugh T.; Fanselow, Michael S. (2012-05-04). "Reinstatement of extinguished fear by an unextinguished conditional stimulus". Frontiers in Behavioral Neuroscience. 6: 18. doi:10.3389/fnbeh.2012.00018. ISSN 1662-5153. PMC 3343277. PMID 22586379.
  27. ^ Zelikowsky, Moriel; Pham, Daniel L.; Fanselow, Michael S. (May 2012). "Temporal factors control hippocampal contributions to fear renewal after extinction". Hippocampus. 22 (5): 1096–1106. doi:10.1002/hipo.20954. ISSN 1050-9631. PMC 3164391. PMID 21618640.
  28. ^ Bissiere, Stephanie; Zelikowsky, Moriel; Ponnusamy, Ravikumar; Jacobs, Nathan S.; Blair, Hugh T.; Fanselow, Michael S. (7 January 2011). "Electrical Synapses Control Hippocampal Contributions to Fear Learning and Memory". Science. 331 (6013): 87–91. Bibcode:2011Sci...331...87B. doi:10.1126/science.1193785. ISSN 0036-8075. PMC 4276370. PMID 21212357.
  29. ^ Krasne, Franklin B.; Fanselow, Michael S.; Zelikowsky, Moriel (2011-07-26). "Design of a Neurally Plausible Model of Fear Learning". Frontiers in Behavioral Neuroscience. 5: 41. doi:10.3389/fnbeh.2011.00041. ISSN 1662-5153. PMC 3145244. PMID 21845175.
  30. ^ "Conditional Analgesia, Negative Feedback, and Error Correction | Request PDF". ResearchGate. Retrieved 2020-03-08.
  31. ^ Zelikowsky, Moriel; Fanselow, Michael S. (August 2010). "Opioid regulation of Pavlovian overshadowing in fear conditioning". Behavioral Neuroscience. 124 (4): 510–519. doi:10.1037/a0020083. ISSN 0735-7044. PMC 2921234. PMID 20695650.
  32. ^ Craske, Michelle G.; Kircanski, Katharina; Zelikowsky, Moriel; Mystkowski, Jayson; Chowdhury, Najwa; Baker, Aaron (January 2008). "Optimizing inhibitory learning during exposure therapy". Behaviour Research and Therapy. 46 (1): 5–27. doi:10.1016/j.brat.2007.10.003. ISSN 0005-7967. PMID 18005936.
  33. ^ "Announcing the 2011 APA Dissertation Research Award recipients". American Psychological Association. Retrieved 2021-08-03.
  34. ^ "Graduate Student Fellowships, Traineeships and Awards Awarded in 2011-2012" (PDF). UCLA Psychology Department. Oct 2012. Retrieved 2021-08-03.
  35. ^ "NSF Award Search: Award # 1306215 - Optogenetic Dissection of a Neural Circuit Underlying the Extinction of PTSD". www.nsf.gov. Retrieved 2021-08-03.
  36. ^ "Whitehall Foundation 2020 Active Grants". www.whitehall.org. Retrieved 2021-08-03.
  37. ^ "Fellows". Klingenstein Philanthropies. Retrieved 2021-08-03.
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