Morc family cw-type zinc finger 1

MORC1
Identifiers
Aliases	MORC1, CT33, MORC, ZCW6, MORC family CW-type zinc finger 1
External IDs	OMIM: 603205; MGI: 1316740; HomoloGene: 7843; GeneCards: MORC1; OMA:MORC1 - orthologs
Gene location (Human)
Chr.	Chromosome 3 (human)
End	109,118,134 bp
Gene location (Mouse)
Chr.	Chromosome 16 (mouse)
End	48,451,263 bp
RNA expression pattern
	Top expressed in
	testicle; ; gonad; ; right testis; ; left testis; ; monocyte; ; duodenum; ; placenta; ; anterior pituitary; ; hippocampus proper; ; substantia nigra;
	Top expressed in
	zygote; ; Gonadal ridge; ; cartilage tissue; ; primary oocyte; ; secondary oocyte; ; blastocyst; ; morula; ; spermatocyte; ; spermatid; ; Meckel's cartilage;
	More reference expression data
	n/a
Gene ontology
Molecular function	zinc ion binding; metal ion binding;
Cellular component	nucleus; male germ cell nucleus;
Biological process	multicellular organism development; cell differentiation; spermatogenesis; negative regulation of transposition; regulation of gene expression, epigenetic; DNA methylation involved in gamete generation; DNA hypermethylation; negative regulation of DNA-templated transcription, initiation; behavioral fear response; negative regulation of gene expression;
	Sources:Amigo / QuickGO
Orthologs
	27136
	17450
	ENSG00000114487
	ENSMUSG00000022652
	Q86VD1
	Q9WVL5
	NM_014429
	NM_010816
	NP_055244
	NP_034946
	Wikidata
View/Edit Human	View/Edit Mouse

MORC family CW-type zinc finger 1 is a protein that in humans is encoded by the MORC1 gene.^[5]

Function

This gene encodes the human homolog of mouse morc and like the mouse protein it is testis-specific. Mouse studies support a testis-specific function since only male knockout mice are infertile; infertility is the only apparent defect. These studies further support a role for this protein early in spermatogenesis, possibly by affecting entry into apoptosis because testis from knockout mice show greatly increased numbers of apoptotic cells. [provided by RefSeq, Jan 2009].

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000114487 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000022652 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: MORC family CW-type zinc finger 1". Retrieved 2018-07-12.

Function

References

Further reading