Benign lymphoepithelial lesion
| Benign lymphoepithelial lesion | |
|---|---|
| Other names | Mikulicz' disease |
 | |
| Specialty | Gastroenterology  |
Benign lymphoepithelial lesion or Mikulicz' disease is a type of benign enlargement of the parotid and/or lacrimal glands. This pathologic state is sometimes, but not always, associated with Sjögren's syndrome.
Signs and symptoms
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Treatment
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Eponym
[edit]Historically, bilateral parotid and lacrimal gland enlargement was characterized by the term Mikulicz's disease if the enlargement appeared apart from other diseases. If it was secondary to another disease, such as tuberculosis, sarcoidosis, lymphoma, and Sjögren's syndrome, the term used was Mikulicz's syndrome. Both names derive from Jan Mikulicz-Radecki, the Polish surgeon best known for describing these conditions.[1][2]
In more recent times, the terms "Mikulicz's disease" and "Mikulicz's syndrome" were viewed as ambiguous and outdated by some sources.[3]
Today Mikulicz's disease is considered to be a subtype of IgG4-related disease, usually accompanied by involvement of one or more other organs in the body.[4]
See also
[edit]References
[edit]- ^ synd/2087 at Who Named It? - "Mikulicz's disease"
- ^ synd/2088 at Who Named It? - "Mikulicz's syndrome"
- ^ Ihrler S, Harrison J (2005). "Mikulicz's disease and Mikulicz's syndrome: analysis of the original case report of 1892 in the light of current knowledge identifies a MALT lymphoma". Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 100 (3): 334–9. doi:10.1016/j.tripleo.2005.01.016. PMID 16122662.
- ^ John H. Stone; Arezou Khosroshahi; Vikram Deshpande; John K. C. Chan; J. Godfrey Heathcote; Rob Aalberse; Atsushi Azumi; Donald B. Bloch; William R. Brugge; Mollie N. Carruthers; Wah Cheuk; Lynn Cornell; Carlos Fernandez-Del Castillo; Judith A. Ferry; David Forcione; Günter Klöppe; Daniel L. Hamilos; Terumi Kamisawa; Satomi Kasashima; Shigeyuki Kawa; Mitsuhiro Kawano; Yasufumi Masaki; Kenji Notohara; Kazuichi Okazaki; Ji Kon Ryu; Takako Saeki; Dushyant Sahani; Yasuharu Sato; Thomas Smyrk; James R. Stone; Masayuki Takahira; Hisanori Umehara; George Webster; Motohisa Yamamoto; Eunhee Yi; Tadashi Yoshino; Giuseppe Zamboni; Yoh Zen; Suresh Chari (October 2012). "Recommendations for the nomenclature of IgG4-related disease and its individual organ system manifestations". Arthritis & Rheumatism. 64 (10): 3061–3067. doi:10.1002/art.34593. PMC 5963880. PMID 22736240.
Further reading
[edit]- Kahn, LB (Jan 1979). "Benign lymphoepithelial lesion (Mikulicz's disease) of the salivary gland: an ultrastructural study". Human Pathology. 10 (1): 99–104. doi:10.1016/S0046-8177(79)80077-5. PMID 428999.
- Lee S, Tsirbas A, McCann J, Goldberg R (2006). "Mikulicz's disease: a new perspective and literature review". Eur J Ophthalmol. 16 (2): 199–203. doi:10.1177/112067210601600201. PMID 16703534. S2CID 24906450.
- Tsubota, K; Fujita, H; Tsuzaka, K; Takeuchi, T (Jun 2000). "Mikulicz's disease and Sjögren's syndrome". Investigative Ophthalmology & Visual Science. 41 (7): 1666–73. PMID 10845583.
- Azzopardi, JG; Evans, DJ (Nov 1971). "Malignant lymphoma of parotid associated with Mikulicz disease (benign lymphoepithelial lesion)". J Clin Pathol. 24 (8): 744–752. doi:10.1136/jcp.24.8.744. PMC 477147. PMID 4943296.
- Yamamoto, M; Harada, S; Ohara, M; Suzuki, C; Naishiro, Y; Yamamoto, H; Takahashi, H; Imai, K (Feb 2005). "Clinical and pathological differences between Mikulicz's disease and Sjögren's syndrome". Rheumatology. 44 (2): 227–34. doi:10.1093/rheumatology/keh447. PMID 15509627.
- Delaney, William E.; Balogh, Károly (1966). "Carcinoma of the parotid gland associated with benign lymphoepithelial lesion (Mikulicz's disease) in Sjögren's syndrome". Cancer. 19 (6): 853–860. doi:10.1002/1097-0142(196606)19:6<853::AID-CNCR2820190617>3.0.CO;2-N. PMID 5939056.
External links
[edit]- Mikulicz syndrome on The National Organization for Rare Disorders (NORD)
- Benign lymphoepithelial lesions on Radiopedia