MicroRNA 375

MIR375
Identifiers
Aliases	MIR375, MIRN375, hsa-mir-375, miRNA375, mir-375, microRNA 375
External IDs	OMIM: 611173; GeneCards: MIR375; OMA:MIR375 - orthologs
Gene location (Human) Chr. Chromosome 2 (human) Band 2q35 Start 219,001,645 bp End 219,001,708 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in islet of Langerhans blood right frontal lobe monocyte placenta stomach muscle layer of sigmoid colon transverse colon right lobe of thyroid gland minor salivary glands n/a More reference expression data BioGPS n/a
Orthologs Species Human Mouse Entrez 494324 n/a Ensembl ENSG00000198973 n/a UniProt n a n/a RefSeq (mRNA) n/a n/a RefSeq (protein) n/a n/a Location (UCSC) Chr 2: 219 – 219 Mb n/a PubMed search n/a
Wikidata
View/Edit Human

MicroRNA 375 is a non coding RNA that in humans is encoded by the MIR375 gene.

Function

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzymes to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into an RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009].

Further reading

• Liu AM, Poon RT, Luk JM (April 2010). "MicroRNA-375 targets Hippo-signaling effector YAP in liver cancer and inhibits tumor properties". Biochem. Biophys. Res. Commun. 394 (3): 623–7. doi:10.1016/j.bbrc.2010.03.036. PMID 20226166.
• Zhao H, Guan J, Lee HM, Sui Y, He L, Siu JJ, Tse PP, Tong PC, Lai FM, Chan JC (August 2010). "Up-regulated pancreatic tissue microRNA-375 associates with human type 2 diabetes through beta-cell deficit and islet amyloid deposition". Pancreas. 39 (6): 843–6. doi:10.1097/MPA.0b013e3181d12613. PMID 20467341. S2CID 23458178.
• Ding L, Xu Y, Zhang W, Deng Y, Si M, Du Y, Yao H, Liu X, Ke Y, Si J, Zhou T (July 2010). "MiR-375 frequently downregulated in gastric cancer inhibits cell proliferation by targeting JAK2". Cell Res. 20 (7): 784–93. doi:10.1038/cr.2010.79. PMID 20548334.
• de Souza Rocha Simonini P, Breiling A, Gupta N, Malekpour M, Youns M, Omranipour R, Malekpour F, Volinia S, Croce CM, Najmabadi H, Diederichs S, Sahin O, Mayer D, Lyko F, Hoheisel JD, Riazalhosseini Y (November 2010). "Epigenetically deregulated microRNA-375 is involved in a positive feedback loop with estrogen receptor alpha in breast cancer cells". Cancer Res. 70 (22): 9175–84. doi:10.1158/0008-5472.CAN-10-1318. PMID 20978187.
• Zhang X, Yan Z, Zhang J, Gong L, Li W, Cui J, Liu Y, Gao Z, Li J, Shen L, Lu Y (October 2011). "Combination of hsa-miR-375 and hsa-miR-142-5p as a predictor for recurrence risk in gastric cancer patients following surgical resection". Ann. Oncol. 22 (10): 2257–66. doi:10.1093/annonc/mdq758. PMID 21343377.
• Li X, Lin R, Li J (October 2011). "Epigenetic silencing of microRNA-375 regulates PDK1 expression in esophageal cancer". Dig. Dis. Sci. 56 (10): 2849–56. doi:10.1007/s10620-011-1711-1. PMID 21533613. S2CID 29745421.
• Szczyrba J, Nolte E, Wach S, Kremmer E, Stöhr R, Hartmann A, Wieland W, Wullich B, Grässer FA (June 2011). "Downregulation of Sec23A protein by miRNA-375 in prostate carcinoma". Mol. Cancer Res. 9 (6): 791–800. doi:10.1158/1541-7786.MCR-10-0573. PMID 21593139.
• Komatsu S, Ichikawa D, Takeshita H, Tsujiura M, Morimura R, Nagata H, Kosuga T, Iitaka D, Konishi H, Shiozaki A, Fujiwara H, Okamoto K, Otsuji E (June 2011). "Circulating microRNAs in plasma of patients with oesophageal squamous cell carcinoma". Br. J. Cancer. 105 (1): 104–11. doi:10.1038/bjc.2011.198. PMC 3137413. PMID 21673684.
• Mazar J, DeBlasio D, Govindarajan SS, Zhang S, Perera RJ (August 2011). "Epigenetic regulation of microRNA-375 and its role in melanoma development in humans". FEBS Lett. 585 (15): 2467–76. doi:10.1016/j.febslet.2011.06.025. PMID 21723283. S2CID 15319974.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.