MicroRNA 148a
| MIR148A | |||||||||||||||||||||||||||||||||||||||||||||||||||
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| Identifiers | |||||||||||||||||||||||||||||||||||||||||||||||||||
| Aliases | MIR148A, MIRN148, MIRN148A, hsa-mir-148, mir-148a, microRNA 148a | ||||||||||||||||||||||||||||||||||||||||||||||||||
| External IDs | OMIM: 613786; GeneCards: MIR148A; OMA:MIR148A - orthologs | ||||||||||||||||||||||||||||||||||||||||||||||||||
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| Wikidata | |||||||||||||||||||||||||||||||||||||||||||||||||||
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MicroRNA 148a is a miRNA that in humans is encoded by the MIR148A gene. [3]
Function
[edit]microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding.
The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products.
The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.
References
[edit]- ^ a b c GRCh38: Ensembl release 89: ENSG00000199085 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Entrez Gene: MicroRNA 148a". Retrieved 2017-09-08.
Further reading
[edit]- Fujita Y, Kojima K, Ohhashi R, Hamada N, Nozawa Y, Kitamoto A, Sato A, Kondo S, Kojima T, Deguchi T, Ito M (2010). "MiR-148a attenuates paclitaxel resistance of hormone-refractory, drug-resistant prostate cancer PC3 cells by regulating MSK1 expression". J. Biol. Chem. 285 (25): 19076–84. doi:10.1074/jbc.M109.079525. PMC 2885186. PMID 20406806.
- Hummel R, Hussey DJ, Michael MZ, Haier J, Bruewer M, Senninger N, Watson DI (2011). "MiRNAs and their association with locoregional staging and survival following surgery for esophageal carcinoma". Ann. Surg. Oncol. 18 (1): 253–60. doi:10.1245/s10434-010-1213-y. PMID 20628822. S2CID 26439245.
- Haflidadóttir BS, Bergsteinsdóttir K, Praetorius C, Steingrímsson E (2010). "miR-148 regulates Mitf in melanoma cells". PLOS ONE. 5 (7): e11574. Bibcode:2010PLoSO...511574H. doi:10.1371/journal.pone.0011574. PMC 2904378. PMID 20644734.
- Murata T, Takayama K, Katayama S, Urano T, Horie-Inoue K, Ikeda K, Takahashi S, Kawazu C, Hasegawa A, Ouchi Y, Homma Y, Hayashizaki Y, Inoue S (2010). "miR-148a is an androgen-responsive microRNA that promotes LNCaP prostate cell growth by repressing its target CAND1 expression". Prostate Cancer Prostatic Dis. 13 (4): 356–61. doi:10.1038/pcan.2010.32. PMID 20820187.
- Giraud-Triboult K, Rochon-Beaucourt C, Nissan X, Champon B, Aubert S, Piétu G (2011). "Combined mRNA and microRNA profiling reveals that miR-148a and miR-20b control human mesenchymal stem cell phenotype via EPAS1" (PDF). Physiol. Genomics. 43 (2): 77–86. doi:10.1152/physiolgenomics.00077.2010. PMID 21081659.
- Muiños-Gimeno M, Espinosa-Parrilla Y, Guidi M, Kagerbauer B, Sipilä T, Maron E, Pettai K, Kananen L, Navinés R, Martín-Santos R, Gratacòs M, Metspalu A, Hovatta I, Estivill X (2011). "Human microRNAs miR-22, miR-138-2, miR-148a, and miR-488 are associated with panic disorder and regulate several anxiety candidate genes and related pathways". Biol. Psychiatry. 69 (6): 526–33. doi:10.1016/j.biopsych.2010.10.010. PMID 21168126. S2CID 206101163.
- Pavicic W, Perkiö E, Kaur S, Peltomäki P (2011). "Altered methylation at microRNA-associated CpG islands in hereditary and sporadic carcinomas: a methylation-specific multiplex ligation-dependent probe amplification (MS-MLPA)-based approach". Mol. Med. 17 (7–8): 726–35. doi:10.2119/molmed.2010.00239. PMC 3146601. PMID 21327300.
- Zhang H, Li Y, Huang Q, Ren X, Hu H, Sheng H, Lai M (2011). "MiR-148a promotes apoptosis by targeting Bcl-2 in colorectal cancer". Cell Death Differ. 18 (11): 1702–10. doi:10.1038/cdd.2011.28. PMC 3190106. PMID 21455217.
- Kulkarni S, Savan R, Qi Y, Gao X, Yuki Y, Bass SE, Martin MP, Hunt P, Deeks SG, Telenti A, Pereyra F, Goldstein D, Wolinsky S, Walker B, Young HA, Carrington M (2011). "Differential microRNA regulation of HLA-C expression and its association with HIV control". Nature. 472 (7344): 495–8. Bibcode:2011Natur.472..495K. doi:10.1038/nature09914. PMC 3084326. PMID 21499264.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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