Methidiumpropyl-EDTA
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| Names | |
|---|---|
| IUPAC name
3,8-Diamino-6-[4-[13-carboxy-9,12-bis(carboxymethyl)-1,7-dioxo-2,6,9,12-tetraazatridec-1-yl]phenyl]-5-methylphenanthridinium
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| Other names
MPE
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| Identifiers | |
3D model (JSmol)
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| ECHA InfoCard | 100.149.943 |
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| Properties | |
| C34H40N7O8 | |
| Molar mass | 674.735 g·mol−1 |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Methidiumpropyl-EDTA (MPE) is composed of the DNA intercalator methidium covalently attached to the metal chelator ethylenediaminetetraacetic acid (EDTA) by a short linker.[1] MPE nonspecifically binds and cleaves DNA at multiple locations.
See also
[edit]References
[edit]- ^ Tanner, N.Kyle; Cech, Thomas R. (1985). "Self-catalyzed cyclization of the intervening sequence RNA of Tetrahymena:inhibition by methidiumpropyl-EDTA and localization of the major dye binding sites". Nucleic Acids Research. 13 (21): 7759–7779. doi:10.1093/nar/13.21.7759. PMC 322085. PMID 2415924.
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