Methenyltetrahydrofolate cyclohydrolase
| methenyltetrahydrofolate cyclohydrolase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
 Methenyltetrahydrofolate cyclohydrolase dimer, Human | |||||||||
| Identifiers | |||||||||
| EC no. | 3.5.4.9 | ||||||||
| CAS no. | 9027-97-8 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
In enzymology, a methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9) is an enzyme that catalyzes the chemical reaction
- 5,10-methenyltetrahydrofolate + H2O 10-formyltetrahydrofolate
Thus, the two substrates of this enzyme are 5,10-methenyltetrahydrofolate and H2O, whereas its product is 10-formyltetrahydrofolate.
This enzyme belongs to the family of hydrolases, those acting on carbon-nitrogen bonds other than peptide bonds, specifically in cyclic amidines.
This enzyme participates in glyoxylate and dicarboxylate metabolism and one carbon pool by folate.
Synonyms
[edit]The systematic name of this enzyme class is 5,10-methenyltetrahydrofolate 5-hydrolase (decyclizing).
Other names in common use include:
- Citrovorum factor cyclodehydrase
- cyclohydrolase
- formyl-methenyl-methylenetetrahydrofolate synthetase (combined).
Structural studies
[edit]As of late 2007, 6 structures have been solved for this class of enzymes, with PDB accession codes 1A4I, 1DIA, 1DIB, 1DIG, 2C2X, and 2C2Y.
References
[edit]- Rabinowitz JC, Pricer WE (1956). "The enzymatic synthesis of N10-formyltetrahydrofolic acid and its role in ATP formation during formiminoglycine degradation". J. Am. Chem. Soc. 78 (16): 4176–4178. doi:10.1021/ja01597a094.
- Tabor H, Wyngarden L (July 1959). "The enzymatic formation of formiminotetrahydrofolic acid, 5,10-methenyltetrahydrofolic acid, and 10-formyltetrahydrofolic acid in the metabolism of formiminoglutamic acid". The Journal of Biological Chemistry. 234 (7): 1830–46. doi:10.1016/S0021-9258(18)69935-1. PMID 13672973.
