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Martin Lauritzen

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Martin Johannes Lauritzen
Danish neuroscientist
OccupationProfessor & senior consultant

Martin Johannes Lauritzen (born 1952) is a Danish neuroscientist.[1] He is a Professor of Translational Neurobiology at the Department of Neuroscience, University of Copenhagen, Denmark and also a Professor of Clinical Neurophysiology at the Department of Neurophysiology, Rigshospitalet (The National Hospital of Denmark).[2]

Early life and education

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Martin Johannes Lauritzen was born in the year 1952 in Copenhagen, Denmark. He earned his medical degree in 1978 and his Doctorate of Science (D.Med.Sci.) in 1988, both from University of Copenhagen, Denmark.[3][4]

Career

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From 1980-85, Lauritzen worked as a Research Associate at the Department of Neurology at Rigshospitalet, at the Department of General Physiology at University of Copenhagen and at the Department of Biophysics and Physiology at New York University. From 1985 to 1994, he got his clinical education at Copenhagen University Hospitals. In 1994, he started working as Senior Consultant and later Head of Department of Clinical Neurophysiology at Glostrup Hospital (later Rigshospitalet Glostrup) and became Clinical Professor of Clinical Neurophysiology at the University of Copenhagen in 1998. In 2004, Lauritzen was a visiting professor at the Department of Experimental Neurology at Klinikum Charité, Humboldt University. Since 2007, Lauritzen is also employed as Professor of Translational Neurobiology at the Department of Neuroscience, University of Copenhagen, Denmark.[5][6] Lauritzen has led a number of large research initiatives including a Strategic Brain Research Program at University of Copenhagen known as ‘Body & Mind’. In 2003, he was a founding member of the steering committee for COSBID, a large multi-center study of elucidating the mechanisms of acute brain disorders with focus on the impact of ‘brain tsunamis’, i.e. cortical spreading depolarization waves for the outcome of patients with brain trauma, hemorrhage and stroke.[7][8] In 2009, Lauritzen was one of the co-founders of the national Center for Healthy Aging (2009), and he has been a principal investigator of the mechanisms of cognitive decline in brain aging including both animal experimental and human research.[9][10][11][12] From 2009–2018, Lauritzen was Editor-in-chief of the Journal of Cerebral Blood Flow and Metabolism and since 2018 he is consulting editor of the Journal.[13] Lauritzen currently serves as Director of the Lundbeck Foundation Research Initiative on Brain Barriers and Drug Delivery.[14]

Work

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Lauritzen studies the mechanism of brain blood vessels, and the regulation of the cerebral circulation and the blood-brain barrier (BBB) in health and disease.[15][16] In his early career, he identified the cortical mechanism that underlie migraine in patients as a cortical spreading depolarization wave,[17] and he showed that the same mechanism contribute importantly to brain pathology in acute brain injuries.[18][19][20] Now, using mouse models he has revealed new elements of the regulation of brain vascular responses to stimulation,[21][22][23][24] and key mechanisms that guide vascular cells to direct oxygen and glucose to active nerve cells.[25][26] Lauritzen has investigated the blood-brain barrier as diffusional barrier for macromolecules, that specific parts of small blood vessels control the trafficking of substances from blood and brain[27] and that signalling molecules in the blood contribute to vascular barrier properties.[28][29] His studies unravel pathophysiological mechanisms in acute brain disorders, and communication pathways between nerve networks and blood vessels needed to control brain energy supply in health and disease.

Awards and honors

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  • 2017: Member of Academia Europaea[30]
  • 2016: Niels A. Lassen Prize[31]
  • 2004: Humboldt Research Award in Medicine (Alexander von Humboldt Stiftung, Germany)[32]
  • 1992: Arnold Friedman Distinguished Clinician/Researcher Award (American Headache Association).[33]
  • 1985: Fulbright Scholarship, Department of Biophysics, New York University, NY, USA.[34]
  • 1982: Harold G. Wolff Award (American Headache Association).[35]
  • 1982: Award of the Danish Neurological Society.[36]

References

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  1. ^ Martin J. Lauritzen, University of Copenhagen "CV"
  2. ^ eMedEvents Speaker Profile
  3. ^ database Kraks Blå Bog
  4. ^ "CV" Martin J. Lauritzen, Rigshospitalet
  5. ^ database Kraks Blå Bog
  6. ^ "CV" Martin J. Lauritzen, Rigshospitalet
  7. ^ RIBBDD homepage
  8. ^ "Cosbid Homepage".
  9. ^ Jessen SB, Brazhe A, Lind BL, Mathiesen C, Thomsen K, Jensen K, et al. GABAA Receptor-Mediated Bidirectional Control of Synaptic Activity, Intracellular Ca2+, Cerebral Blood Flow, and Oxygen Consumption in Mouse Somatosensory Cortex In Vivo. CerebCortex. 2014.
  10. ^ Jessen SB, Mathiesen C, Lind BL, Lauritzen M. Interneuron Deficit Associates Attenuated Network Synchronization to Mismatch of Energy Supply and Demand in Aging Mouse Brains. CerebCortex. 2015.
  11. ^ Wiegand I, Lauritzen MJ, Osler M, Mortensen EL, Rostrup E, Rask L, et al. EEG correlates of visual short-term memory in older age vary with adult lifespan cognitive development. Neurobiol Aging. 2018;62:210-20.
  12. ^ Horwitz A, Klemp M, Horwitz H, Thomsen MD, Rostrup E, Mortensen EL, et al. Brain Responses to Passive Sensory Stimulation Correlate With Intelligence. Front Aging Neurosci. 2019;11:201.
  13. ^ Journal of Cerebral Blood Flow and Metabolism - Editorial Board
  14. ^ RIBBDD homepage
  15. ^ Lauritzen M, Mathiesen C, Schaefer K, Thomsen KJ. Neuronal inhibition and excitation, and the dichotomic control of brain hemodynamic and oxygen responses. Neuroimage. 2012.
  16. ^ Ayata C, Lauritzen M. Spreading Depression, Spreading Depolarizations, and the Cerebral Vasculature. Physiol Rev. 2015;95(3):953-93.
  17. ^ Lauritzen M. Pathophysiology of the migraine aura. The spreading depression theory. Brain. 1994;117(Pt 1):199-210.
  18. ^ Strong AJ, Fabricius M, Boutelle MG, Hibbins SJ, Hopwood SE, Jones R, et al. Spreading and synchronous depressions of cortical activity in acutely injured human brain. Stroke. 2002;33(12):2738-43.
  19. ^ Fabricius M, Fuhr S, Bhatia R, Boutelle M, Hashemi P, Strong AJ, et al. Cortical spreading depression and peri-infarct depolarization in acutely injured human cerebral cortex. Brain. 2006;129:778-90.
  20. ^ Lauritzen M, Dreier JP, Fabricius M, Hartings JA, Graf R, Strong AJ. Clinical relevance of cortical spreading depression in neurological disorders: migraine, malignant stroke, subarachnoid and intracranial hemorrhage, and traumatic brain injury. JCerebBlood Flow Metab. 2011;31(1):17-35.
  21. ^ Hall CN, Reynell C, Gesslein B, Hamilton NB, Mishra A, Sutherland BA, et al. Capillary pericytes regulate cerebral blood flow in health and disease. Nature. 2014;508(7494):55-60.
  22. ^ Grubb S, Cai C, Hald BO, Khennouf L, Murmu RP, Jensen AGK, et al. Precapillary sphincters maintain perfusion in the cerebral cortex. Nat Commun. 2020;11(1):395.
  23. ^ Mathiesen C, Caesar K, Akgoren N, Lauritzen M. Modification of activity-dependent increases of cerebral blood flow by excitatory synaptic activity and spikes in rat cerebellar cortex. Journal of Physiology. 1998;512(Pt 2):555-66.
  24. ^ Lauritzen M. Opinion: Reading vascular changes in brain imaging: is dendritic calcium the key? NatRevNeurosci. 2005;6(1):77-85.
  25. ^ Cai C, Fordsmann JC, Jensen SH, Gesslein B, Lonstrup M, Hald BO, et al. Stimulation-induced increases in cerebral blood flow and local capillary vasoconstriction depend on conducted vascular responses. Proc Natl Acad Sci U S A. 2018;115(25):E5796-E804.
  26. ^ Khennouf L, Gesslein B, Brazhe A, Octeau JC, Kutuzov N, Khakh BS, et al. Active role of capillary pericytes during stimulation-induced activity and spreading depolarization. Brain. 2018;141(7):2032-46.
  27. ^ Kucharz, Krzysztof; Kristensen, Kasper; Johnsen, Kasper Bendix; Lund, Mette Aagaard; Lønstrup, Micael; Moos, Torben; Andresen, Thomas Lars; Lauritzen, Martin Johannes (2021-07-05). "Post-capillary venules are the key locus for transcytosis-mediated brain delivery of therapeutic nanoparticles". Nature Communications. 12 (1): 4121. Bibcode:2021NatCo..12.4121K. doi:10.1038/s41467-021-24323-1. ISSN 2041-1723. PMC 8257611. PMID 34226541.
  28. ^ Kucharz, Krzysztof; Kristensen, Kasper; Johnsen, Kasper Bendix; Lund, Mette Aagaard; Lønstrup, Micael; Moos, Torben; Andresen, Thomas Lars; Lauritzen, Martin Johannes (2021-07-05). "Post-capillary venules are the key locus for transcytosis-mediated brain delivery of therapeutic nanoparticles". Nature Communications. 12 (1): 4121. Bibcode:2021NatCo..12.4121K. doi:10.1038/s41467-021-24323-1. ISSN 2041-1723. PMC 8257611. PMID 34226541.
  29. ^ Mathiesen Janiurek M, Soylu-Kucharz R, Christoffersen C, Kucharz K, Lauritzen M. Apolipoprotein M-bound sphingosine-1-phosphate regulates blood-brain barrier paracellular permeability and transcytosis. Elife. 2019;8.
  30. ^ "Academy of Europe: Lauritzen J. Martin".
  31. ^ "Niels A. Lassen Prize".
  32. ^ "Humboldt Research Award in Medicine".
  33. ^ "CV" Martin J. Lauritzen, Rigshospitalet
  34. ^ "CV" Martin J. Lauritzen, Rigshospitalet
  35. ^ "CV" Martin J. Lauritzen, Rigshospitalet
  36. ^ "CV" Martin J. Lauritzen, Rigshospitalet
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