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Mario Deng

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Mario Chih-Hsiung Karl Deng
NationalityGerman, American
EducationUniversity of Hamburg,
Free University of Berlin,
Stanford University
AwardsForbes 27 Top Cardiologists
Scientific career
FieldsCardiology

Mario Chih-Hsiung Karl Deng is a German-Chinese cardiologist specialized in the care of patients with advanced heart failure. Deng is a Professor of Medicine in the David Geffen School of Medicine at the University of California, Los Angeles.

Biography

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Deng was born in West Berlin as the only child of a Chinese forestry scientist (father) and a German lawyer (mother).[1] In 1992–1993, he spent time as a post-doctoral fellow at Stanford University for training in advanced heart failure, transplantation cardiology and molecular cardiology.[2] From 1992 to 2000, Deng became a professor at the University of Münster, building the Interdisciplinary Heart Failure and Heart Transplant Program[3] of Muenster University. In 2000, Deng joined Columbia University as the Director of Cardiac Transplantation Research.[4] In 2001, Deng was appointed the founding Medical Director of the Mechanical Circulatory Support Database [5] of the International Society for Heart and Lung Transplantation. In 2011, he was recruited to the University of California, Los Angeles to re-build the Heart Transplant Program as Director of the Advanced Heart Failure, Mechanical Circulatory Support, and Heart Transplant Program.[6]

Career

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Multidisciplinary care and clinical outcomes in advanced heart failure

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Deng was responsible for the conduct and publication of the Comparative Outcomes and Clinical Profiles in Transplantation (COCPIT Study)[7] which contributed to the discussion about reorganization of the heart allocation rules in Europe and the United States.[8]

Development of a blood test to detect cardiac rejection

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Deng co-developed the first in history diagnostic and prognostic peripheral blood mononuclear cell gene expression profiling biomarker test[9] in heart transplantation medicine that gained US-FDA-regulatory clearance [10] and international evidence-based medicine guideline acceptance [11] to rule out rejection without invasive biopsies [12][13][14][15]

Development of a blood test to predict survival in heart failure

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Since 2005, the Deng lab started to develop a genomic blood test to better predict outcomes in patients with various forms of advanced heart failure[16][17]

Development of a humanistic framework in high-tech medicine

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The creation of a framework to personalize high–tech modern medicine encounters is reflected in Deng's research collaboration with Professor Federica Raia (UCLA Graduate School of Education and Information Studies and David Geffen School of Medicine) in the "Relational Medicine" project.[18][19] Deng is Co-Founder and Co-President of the Relational Medicine Foundation.

Selected publications

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  • Deng MC, De Meester JMJ, Smits JMA, Heinecke J, Scheld HH, on behalf of COCPIT Study Group. The impact of heart failure severity on outcome in cardiac transplant candidates. Br Med J 2000;321:540–545. PMCID: PMC4133547.
  • Deng MC, Edwards LB, Taylor DO, Hertz MI, Rowe AW, Keck B, Kormos RL, Naftel D, Kirklin J. Mechanical circulatory support device database of the international society for heart and lung transplantation: third annual report-2005. J Heart Lung Transplant 2005;24:1182–1187. PMID 16143231
  • Deng MC, Eisen HJ, Mehra RM, Billingham M, Marboe CC, Berry G, Kobashigawa J, Johnson FL, Starling RC, Murali S, Pauly DF, Baron H, Wohlgemuth JG, Woodward RN, Klingler TM, Walther D, Lal PG, Rosenberg S, Hunt SA, for the CARGO Investigators. Non-invasive detection of rejection in cardiac allograft recipients using gene expression profiling. Am J Transplant 2006;6:150–160. PMID 23602870.
  • Deng MC, Elashoff B, Pham MX, Teuteberg JJ, Kfoury AG, Starling RC, Cappola TP, Kao A, Anderson AS, Cotts WG, Ewald GA, Baran DA, Bogaev RC, Shahzad K, Hiller D, Yee J, Valantine HA; for the IMAGE Study Group. Utility of Gene Expression Profiling Score Variability to Predict Clinical Events in Heart Transplant Recipients. Transplantation. 2014 Jan 31. [Epub ahead of print] PMID 24492465 [PubMed - as supplied by publisher]
  • Bondar G, Togashi R, Cadeiras M, Schaenman J, Cheng RK, Masukawa L, Hai J, Bao TM, Chu D, Chang E, Bakir M, Kupiec-Weglinski S, Groysberg V, Grogan T, Meltzer J, Kwon M, Rossetti M, Elashoff D, Reed E, Ping PP, Deng MC. Association between preoperative peripheral blood mononuclear cell gene expression profiles, early postoperative organ function recovery potential and long-term survival in advanced heart failure patients undergoing mechanical circulatory support. PLoS One. 2017 Dec 13;12(12). PMCID: PMC5728510.
  • Raia F, Deng MC. Relational Medicine – Personalizing Modern Healthcare: The Practice of High-Tech Medicine As A RelationalAct. World Scientific Publishing/Imperial College Press, London/Singapore 2014 Deng 2014C

References

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  1. ^ "Professor Mario Deng: Bypässe für Bill Clinton". Die Welt. January 7, 2007 – via www.welt.de.
  2. ^ "Prior Fellows". Cardiovascular Medicine.
  3. ^ Deng, M. C.; Breithardt, G.; Scheld, H. H. (1995). "The Interdisciplinary Heart Failure and Transplant Program Münster: A 5-year experience". International Journal of Cardiology. 50 (1): 7–17. doi:10.1016/0167-5273(95)02344-V. PMID 7558467.
  4. ^ Ärzteblatt, Deutscher Ärzteverlag GmbH, Redaktion Deutsches (November 24, 2000). "Universitäten". Deutsches Ärzteblatt.{{cite web}}: CS1 maint: multiple names: authors list (link)
  5. ^ Deng, Mario C.; Edwards, Leah B.; Hertz, Marshall I.; Rowe, Amanda W.; Keck, Berkeley M.; Kormos, Robert; Naftel, David C.; Kirklin, James K.; Taylor, David O.; International Society for Heart Lung Transplantation (2005). "Mechanical Circulatory Support Device Database of the International Society for Heart and Lung Transplantation: Third Annual Report—2005⁎ ⁎All figures and tables from this report, and a more comprehensive set of ISHLT registry slides are available at www.ishlt.org/registries/". The Journal of Heart and Lung Transplantation. 24 (9): 1182–1187. doi:10.1016/j.healun.2005.07.002. PMID 16143231.
  6. ^ "Dr. Mario C. Deng – U Magazine – UCLA Health – Los Angeles, CA". uclahealth.org.
  7. ^ Deng, M. C.; De Meester, J. M.; Smits, J. M.; Heinecke, J.; Scheld, H. H. (2000). "Effect of receiving a heart transplant: Analysis of a national cohort entered on to a waiting list, stratified by heart failure severity. Comparative Outcome and Clinical Profiles in Transplantation (COCPIT) Study Group". BMJ (Clinical Research Ed.). 321 (7260): 540–5. doi:10.1136/bmj.321.7260.540. PMC 27468. PMID 10968814.
  8. ^ "BBC News | HEALTH | Heart transplants 'only benefit sickest'". news.bbc.co.uk.
  9. ^ Deng, M. C.; Eisen, H. J.; Mehra, M. R.; Billingham, M.; Marboe, C. C.; Berry, G.; Kobashigawa, J.; Johnson, F. L.; Starling, R. C.; Murali, S.; Pauly, D. F.; Baron, H.; Wohlgemuth, J. G.; Woodward, R. N.; Klingler, T. M.; Walther, D.; Lal, P. G.; Rosenberg, S.; Hunt, S. (2006). "Noninvasive Discrimination of Rejection in Cardiac Allograft Recipients Using Gene Expression Profiling". American Journal of Transplantation. 6 (1): 150–160. doi:10.1111/j.1600-6143.2005.01175.x. PMID 16433769.
  10. ^ "510(k) SUBSTANTIAL EQUIVALENCE DETERMINATION DECISION SUMMARY ASSAY AND INSTRUMENT COMBINATION TEMPLATE" (PDF). Retrieved 7 July 2024.
  11. ^ "HeartCare" (PDF).
  12. ^ "Genetic Test Can Detect Heart Transplant Rejection". Consumer HealthDay. 28 December 2005.
  13. ^ "Genomics-Based Test Replaces Heart Biopsy" (PDF). Retrieved 7 July 2024.
  14. ^ "Accuracy Of Gene Expression Test For Heart Transplant Patients Confirmed By Independent Clinical Data". Columbia University Irving Medical Center. December 21, 2006.
  15. ^ "Blood test serves as 'crystal ball' for heart transplant patients, UCLA-led study finds". UCLA.
  16. ^ Bondar, Galyna; Togashi, Ryan; Cadeiras, Martin; Schaenman, Joanna; Cheng, Richard K.; Masukawa, Lindsay; Hai, Josephine; Bao, Tra-Mi; Chu, Desai; Chang, Eleanor; Bakir, Maral; Kupiec-Weglinski, Sophie; Groysberg, Victoria; Grogan, Tristan; Meltzer, Joseph; Kwon, Murray; Rossetti, Maura; Elashoff, David; Reed, Elaine; Ping, Pei Pei; Deng, Mario C. (2017). "Association between preoperative peripheral blood mononuclear cell gene expression profiles, early postoperative organ function recovery potential and long-term survival in advanced heart failure patients undergoing mechanical circulatory support". PLOS ONE. 12 (12): e0189420. Bibcode:2017PLoSO..1289420B. doi:10.1371/journal.pone.0189420. PMC 5728510. PMID 29236770.
  17. ^ "Genomic blood test predicts survival rates after surgery for advanced heart failure". UCLA.
  18. ^ "Federica Raia: Book on Relational Medicine Reveals Doctor-Patient Collaboration | UCLA GSE&IS Ampersand". ampersand.gseis.ucla.edu.
  19. ^ Albin, Amy (October 17, 2018). "Former Bruin football player tackles life following heart transplant". UCLA Health. Retrieved 5 July 2020.
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