Princess Maria Anna of Naples and Sicily (Italian: Maria Anna Giuseppa Antonietta Francesca Gaetana Teresa Amalia Clementina; 23 November 1775 – 22 February 1780) was a member of the Spanish Royal Family (branched out to the Kingdom of the Two Sicilies).
Due to the fact that Maria Anna was born just ten months after her older brother Carlo Francesco Giuseppe Gennaro, her birth was extremely difficult for Maria Carolina, and thus for the baby too. She was a very frail and weak child. Her health was reason for debate and when her brother Carlo, Duke of Calabria became ill with smallpox, he was immediately transferred to the Caserta Palace in order to prevent Maria Anna from getting sick, too. Carlo eventually succumbed to the illness on 17 December 1778, aged just three.
In 1778, against all efforts, she contracted smallpox. She rallied for a while, but died on 22 February 1780.
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