Mannitol 2-dehydrogenase (NADP+)
Appearance
mannitol 2-dehydrogenase (NADP+) | |||||||||
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Identifiers | |||||||||
EC no. | 1.1.1.138 | ||||||||
CAS no. | 37250-68-3 | ||||||||
Databases | |||||||||
IntEnz | IntEnz view | ||||||||
BRENDA | BRENDA entry | ||||||||
ExPASy | NiceZyme view | ||||||||
KEGG | KEGG entry | ||||||||
MetaCyc | metabolic pathway | ||||||||
PRIAM | profile | ||||||||
PDB structures | RCSB PDB PDBe PDBsum | ||||||||
Gene Ontology | AmiGO / QuickGO | ||||||||
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In enzymology, a mannitol 2-dehydrogenase (NADP+) (EC 1.1.1.138) is an enzyme that catalyzes the chemical reaction
- D-mannitol + NADP+ D-fructose + NADPH + H+
Thus, the two substrates of this enzyme are D-mannitol and NADP+, whereas its 3 products are D-fructose, NADPH, and H+.
This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is D-mannitol:NADP+ 2-oxidoreductase. This enzyme is also called mannitol 2-dehydrogenase (NADP+). This enzyme participates in fructose and mannose metabolism.
Structural studies
[edit]As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code 1H5Q.
References
[edit]- Edmundowicz JM, Wriston JC (1963). "Mannitol dehydrogenase from Agaricus campestris". J. Biol. Chem. 238 (11): 3539–41. doi:10.1016/S0021-9258(19)75304-6. PMID 14109183.
- Strobel GA; Kosuge T (1965). "Polyol metabolism in Diplodia viticola Desm". Arch. Biochem. Biophys. 109 (3): 622–626. doi:10.1016/0003-9861(65)90409-1. PMID 14320506.