Jump to content

Mannitol 2-dehydrogenase

From Wikipedia, the free encyclopedia
mannitol 2-dehydrogenase
Identifiers
EC no.1.1.1.67
CAS no.9001-65-4
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO
Search
PMCarticles
PubMedarticles
NCBIproteins

In enzymology, a mannitol 2-dehydrogenase (EC 1.1.1.67) is an enzyme that catalyzes the chemical reaction

D-mannitol + NAD+ D-fructose + NADH + H+

Thus, the two substrates of this enzyme are D-mannitol and NAD+, whereas its 3 products are D-fructose, NADH, and H+.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is D-mannitol:NAD+ 2-oxidoreductase. Other names in common use include D-mannitol dehydrogenase, and mannitol dehydrogenase. This enzyme participates in fructose and mannose metabolism.

Structural studies

[edit]

As of late 2007, two structures have been solved for this class of enzymes, with PDB accession codes 1LJ8 and 1M2W.

References

[edit]
  • Martinez G, Barker HA, Horecker BL (1963). "A specific mannitol dehydrogenase from Lactobacillus brevis". J. Biol. Chem. 238 (5): 1598–1603. doi:10.1016/S0021-9258(18)81106-1.