Mannitol 2-dehydrogenase
Appearance
mannitol 2-dehydrogenase | |||||||||
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Identifiers | |||||||||
EC no. | 1.1.1.67 | ||||||||
CAS no. | 9001-65-4 | ||||||||
Databases | |||||||||
IntEnz | IntEnz view | ||||||||
BRENDA | BRENDA entry | ||||||||
ExPASy | NiceZyme view | ||||||||
KEGG | KEGG entry | ||||||||
MetaCyc | metabolic pathway | ||||||||
PRIAM | profile | ||||||||
PDB structures | RCSB PDB PDBe PDBsum | ||||||||
Gene Ontology | AmiGO / QuickGO | ||||||||
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In enzymology, a mannitol 2-dehydrogenase (EC 1.1.1.67) is an enzyme that catalyzes the chemical reaction
- D-mannitol + NAD+ D-fructose + NADH + H+
Thus, the two substrates of this enzyme are D-mannitol and NAD+, whereas its 3 products are D-fructose, NADH, and H+.
This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is D-mannitol:NAD+ 2-oxidoreductase. Other names in common use include D-mannitol dehydrogenase, and mannitol dehydrogenase. This enzyme participates in fructose and mannose metabolism.
Structural studies
[edit]As of late 2007, two structures have been solved for this class of enzymes, with PDB accession codes 1LJ8 and 1M2W.
References
[edit]- Martinez G, Barker HA, Horecker BL (1963). "A specific mannitol dehydrogenase from Lactobacillus brevis". J. Biol. Chem. 238 (5): 1598–1603. doi:10.1016/S0021-9258(18)81106-1.