Mammaglobin-B

SCGB2A1
Identifiers
Aliases	SCGB2A1, LPHC, LPNC, MGB2, UGB3, secretoglobin family 2A member 1
External IDs	OMIM: 604398; HomoloGene: 88664; GeneCards: SCGB2A1; OMA:SCGB2A1 - orthologs
Gene location (Human)
Chr.	Chromosome 11 (human)
End	62,213,943 bp
Gene location (Mouse)
Chr.	Chromosome 19 (mouse)
End	9,852,808 bp
RNA expression pattern
	Top expressed in
	corpus epididymis; ; right uterine tube; ; caput epididymis; ; olfactory zone of nasal mucosa; ; beta cell; ; bronchial epithelial cell; ; endometrium; ; nasal epithelium; ; tail of epididymis; ; mucosa of paranasal sinus;
	Top expressed in
	embryo; ; embryo; ; genital tubercle;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein heterodimerization activity;
Cellular component	extracellular space; extracellular region;
Biological process	androgen receptor signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	4246
	102639117
	ENSG00000124939
	ENSMUSG00000096872
	O75556
	J3KMP9
	NM_002407
	XM_006527538
	NP_002398
	NP_001365339
	Wikidata
View/Edit Human	View/Edit Mouse

Mammaglobin-B also known as secretoglobin family 2A member 1 is a protein that in humans is encoded by the SCGB2A1 gene.^[5]^[6]

SCGB2A1 and breast cancer

SCGB2A1 expression is highly specific of mammary tissue, and has been used for identification and detection of disseminated breast cancer cells.^[7]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000124939 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000096872 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Becker RM, Darrow C, Zimonjic DB, Popescu NC, Watson MA, Fleming TP (Jan 1999). "Identification of mammaglobin B, a novel member of the uteroglobin gene family". Genomics. 54 (1): 70–8. doi:10.1006/geno.1998.5539. PMID 9806831.
^ "Entrez Gene: SCGB2A1 secretoglobin, family 2A, member 1".
^ Lacroix, M (2006). "Significance, detection and markers of disseminated breast cancer cells". Endocrine-Related Cancer. 13 (4). Bioscientifica: 1033–1067. doi:10.1677/ERC-06-0001. PMID 17158753.

Molloy MP, Bolis S, Herbert BR, et al. (1998). "Establishment of the human reflex tear two-dimensional polyacrylamide gel electrophoresis reference map: new proteins of potential diagnostic value". Electrophoresis. 18 (15): 2811–5. doi:10.1002/elps.1150181516. PMID 9504814. S2CID 39202047.
Lehrer RI, Xu G, Abduragimov A, et al. (1998). "Lipophilin, a novel heterodimeric protein of human tears". FEBS Lett. 432 (3): 163–7. Bibcode:1998FEBSL.432..163L. doi:10.1016/S0014-5793(98)00852-7. PMID 9720917. S2CID 205880914.
Zhao C, Nguyen T, Yusifov T, et al. (1999). "Lipophilins: human peptides homologous to rat prostatein". Biochem. Biophys. Res. Commun. 256 (1): 147–55. doi:10.1006/bbrc.1999.0274. PMID 10066439.
Evans V, Vockler C, Friedlander M, et al. (2001). "Lacryglobin in human tears, a potential marker for cancer". Clin. Experiment. Ophthalmol. 29 (3): 161–3. doi:10.1046/j.1442-9071.2001.00408.x. PMID 11446459. S2CID 41723656.
Carter D, Douglass JF, Cornellison CD, et al. (2002). "Purification and characterization of the mammaglobin/lipophilin B complex, a promising diagnostic marker for breast cancer". Biochemistry. 41 (21): 6714–22. doi:10.1021/bi0159884. PMID 12022875.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Izmailova E, Bertley FM, Huang Q, et al. (2003). "HIV-1 Tat reprograms immature dendritic cells to express chemoattractants for activated T cells and macrophages". Nat. Med. 9 (2): 191–7. doi:10.1038/nm822. PMID 12539042. S2CID 26145639.
Sjödin A, Guo D, Sørhaug S, et al. (2003). "Dysregulated secretoglobin expression in human lung cancers". Lung Cancer. 41 (1): 49–56. doi:10.1016/S0169-5002(03)00126-0. PMID 12826312.
Ouellette RJ, Richard D, Maïcas E (2004). "RT-PCR for mammaglobin genes, MGB1 and MGB2, identifies breast cancer micrometastases in sentinel lymph nodes". Am. J. Clin. Pathol. 121 (5): 637–43. doi:10.1309/MMAC-TXT5-5L8Q-TKC1. PMID 15151203.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Xiao F, Mirwald A, Papaioannou M, et al. (2006). "Secretoglobin 2A1 is under selective androgen control mediated by a peculiar binding site for Sp family transcription factors". Mol. Endocrinol. 19 (12): 2964–78. doi:10.1210/me.2004-0408. PMID 16020486.
Bernstein JL, Godbold JH, Raptis G, et al. (2005). "Identification of mammaglobin as a novel serum marker for breast cancer". Clin. Cancer Res. 11 (18): 6528–35. doi:10.1158/1078-0432.CCR-05-0415. PMID 16166429.

This article on a gene on human chromosome 11 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000124939 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000096872 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9806831-5] Becker RM, Darrow C, Zimonjic DB, Popescu NC, Watson MA, Fleming TP (Jan 1999). "Identification of mammaglobin B, a novel member of the uteroglobin gene family". Genomics. 54 (1): 70–8. doi:10.1006/geno.1998.5539. PMID 9806831.

[entrez-6] "Entrez Gene: SCGB2A1 secretoglobin, family 2A, member 1".

[Lacroix06-7] Lacroix, M (2006). "Significance, detection and markers of disseminated breast cancer cells". Endocrine-Related Cancer. 13 (4). Bioscientifica: 1033–1067. doi:10.1677/ERC-06-0001. PMID 17158753.

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SCGB2A1 and breast cancer

References

Further reading