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MYCBP

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(Redirected from MYCBP (gene))
MYCBP
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesMYCBP, AMY-1, MYC binding protein
External IDsOMIM: 606535; MGI: 1891750; HomoloGene: 49312; GeneCards: MYCBP; OMA:MYCBP - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_012333

NM_019660

RefSeq (protein)

NP_036465

NP_062634

Location (UCSC)Chr 1: 38.86 – 38.87 MbChr 4: 123.8 – 123.81 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

C-Myc-binding protein is a protein that in humans is encoded by the MYCBP gene.[5][6]

Function

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The MYCBP gene encodes a protein that binds to the N-terminal region of MYC (MIM 190080) and stimulates the activation of E box-dependent transcription by MYC.[supplied by OMIM][6]

Interactions

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MYCBP has been shown to interact with AKAP1,[7][8] C3orf15[7] and Myc.[5]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000214114Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000028647Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b Taira T, Maëda J, Onishi T, Kitaura H, Yoshida S, Kato H, Ikeda M, Tamai K, Iguchi-Ariga SM, Ariga H (Aug 1998). "AMY-1, a novel C-MYC binding protein that stimulates transcription activity of C-MYC". Genes to Cells. 3 (8): 549–65. doi:10.1046/j.1365-2443.1998.00206.x. PMID 9797456.
  6. ^ a b "Entrez Gene: MYCBP c-myc binding protein".
  7. ^ a b Yukitake H, Furusawa M, Taira T, Iguchi-Ariga SM, Ariga H (Nov 2002). "AAT-1, a novel testis-specific AMY-1-binding protein, forms a quaternary complex with AMY-1, A-kinase anchor protein 84, and a regulatory subunit of cAMP-dependent protein kinase and is phosphorylated by its kinase". The Journal of Biological Chemistry. 277 (47): 45480–92. doi:10.1074/jbc.M206201200. PMID 12223483.
  8. ^ Furusawa M, Ohnishi T, Taira T, Iguchi-Ariga SM, Ariga H (Sep 2001). "AMY-1, a c-Myc-binding protein, is localized in the mitochondria of sperm by association with S-AKAP84, an anchor protein of cAMP-dependent protein kinase". The Journal of Biological Chemistry. 276 (39): 36647–51. doi:10.1074/jbc.M103885200. PMID 11483602.

Further reading

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