MTFMT

MTFMT
Identifiers
Aliases	MTFMT, COXPD15, FMT1, mitochondrial methionyl-tRNA formyltransferase, MC1DN27
External IDs	OMIM: 611766; MGI: 1916856; HomoloGene: 12320; GeneCards: MTFMT; OMA:MTFMT - orthologs
Gene location (Human)
Chr.	Chromosome 15 (human)
End	65,029,639 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	65,360,336 bp
RNA expression pattern
	Top expressed in
	myocardium of left ventricle; ; buccal mucosa cell; ; cardiac muscle tissue of right atrium; ; gastrocnemius muscle; ; mucosa of transverse colon; ; gonad; ; tibial arteries; ; right auricle; ; stromal cell of endometrium; ; muscle of thigh;
	Top expressed in
	medullary collecting duct; ; proximal tubule; ; renal corpuscle; ; right kidney; ; secondary oocyte; ; primary oocyte; ; yolk sac; ; spermatocyte; ; ventricular zone; ; gastrula;
	More reference expression data
	n/a
Gene ontology
Molecular function	transferase activity; hydroxymethyl-, formyl- and related transferase activity; catalytic activity; methionyl-tRNA formyltransferase activity;
Cellular component	mitochondrion;
Biological process	conversion of methionyl-tRNA to N-formyl-methionyl-tRNA; biosynthesis; protein biosynthesis; translational initiation;
	Sources:Amigo / QuickGO
Orthologs
	123263
	69606
	ENSG00000103707
	ENSMUSG00000059183
	Q96DP5
	Q9D799
	NM_139242
	NM_027134
	NP_640335
	NP_081410
	Wikidata
View/Edit Human	View/Edit Mouse

Mitochondrial methionyl-tRNA formyltransferase is a protein that in humans is encoded by the MTFMT gene.^[5]

The protein encoded by this nuclear gene localizes to the mitochondrion, where it catalyzes the formylation of methionyl-tRNA.^[5] Recessive-type mutations in MTFMT have been shown to cause mitochondrial disease.^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000103707 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000059183 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b "Entrez Gene: Mitochondrial methionyl-tRNA formyltransferase". Retrieved 2011-09-20.
^ Tucker EJ, Hershman SG, Köhrer C, Belcher-Timme CA, Patel J, Goldberger OA, et al. (September 2011). "Mutations in MTFMT underlie a human disorder of formylation causing impaired mitochondrial translation". Cell Metabolism. 14 (3): 428–434. doi:10.1016/j.cmet.2011.07.010. PMC 3486727. PMID 21907147.

References

Further reading