MT1H

MT1H
Identifiers
Aliases	MT1H, MT-0, MT-1H, MT-IH, MT1, metallothionein 1H
External IDs	OMIM: 156354; HomoloGene: 136530; GeneCards: MT1H; OMA:MT1H - orthologs
Gene location (Human)
Chr.	Chromosome 16 (human)
End	56,671,129 bp
RNA expression pattern
	Top expressed in
	mucosa of ileum; ; mucosa of transverse colon; ; kidney tubule; ; buccal mucosa cell; ; metanephric glomerulus; ; external globus pallidus; ; cartilage tissue; ; pericardium; ; internal globus pallidus; ; olfactory bulb;
	n/a
	More reference expression data
	n/a
Gene ontology
Molecular function	zinc ion binding; protein binding; metal ion binding;
Cellular component	cytoplasm; perinuclear region of cytoplasm; nucleus;
Biological process	negative regulation of growth; cellular response to cadmium ion; cellular response to zinc ion; cellular zinc ion homeostasis; detoxification of copper ion; cellular response to copper ion;
	Sources:Amigo / QuickGO
Orthologs
	4496
	n/a
	ENSG00000205358
	n/a
	P80294
	n/a
	NM_005951
	n/a
	NP_005942
	n/a
	Wikidata
View/Edit Human

Metallothionein-1H is a protein that in humans is encoded by the MT1H gene.^[3]^[4]^[5]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000205358 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ West AK, Stallings R, Hildebrand CE, Chiu R, Karin M, Richards RI (Mar 1991). "Human metallothionein genes: structure of the functional locus at 16q13". Genomics. 8 (3): 513–8. doi:10.1016/0888-7543(90)90038-V. PMID 2286373.
^ Stennard FA, Holloway AF, Hamilton J, West AK (Sep 1994). "Characterisation of six additional human metallothionein genes". Biochim Biophys Acta. 1218 (3): 357–65. doi:10.1016/0167-4781(94)90189-9. PMID 8049263.
^ "Entrez Gene: MT1H metallothionein 1H".

Soumillion A, Van Damme J, De Ley M (1992). "Cloning and specific polymerised-chain-reaction amplification of a third charge-separable human metallothionein isoform". Eur. J. Biochem. 209 (3): 999–1004. doi:10.1111/j.1432-1033.1992.tb17374.x. PMID 1425708.
Pauwels M, van Weyenbergh J, Soumillion A, et al. (1994). "Induction by zinc of specific metallothionein isoforms in human monocytes". Eur. J. Biochem. 220 (1): 105–10. doi:10.1111/j.1432-1033.1994.tb18603.x. PMID 8119276.
Mididoddi S, McGuirt JP, Sens MA, et al. (1996). "Isoform-specific expression of metallothionein mRNA in the developing and adult human kidney". Toxicol. Lett. 85 (1): 17–27. doi:10.1016/0378-4274(96)03632-6. PMID 8619255.
Vandeghinste N, Proost P, De Ley M (2000). "Metallothionein isoform gene expression in zinc-treated human peripheral blood lymphocytes". Cell. Mol. Biol. (Noisy-le-grand). 46 (2): 419–33. PMID 10774930.
Nguyen A, Jing Z, Mahoney PS, et al. (2000). "In vivo gene expression profile analysis of metallothionein in renal cell carcinoma". Cancer Lett. 160 (2): 133–40. doi:10.1016/S0304-3835(00)00534-6. PMID 11053642.
Rahman MT, Vandingenen A, De Ley M (2000). "Metallothionein biosynthesis in human RBC precursors". Cell. Physiol. Biochem. 10 (4): 237–42. doi:10.1159/000016355. PMID 11093034. S2CID 22377545.
Chen Y, Irie Y, Keung WM, Maret W (2002). "S-nitrosothiols react preferentially with zinc thiolate clusters of metallothionein III through transnitrosation". Biochemistry. 41 (26): 8360–7. doi:10.1021/bi020030+. PMID 12081484.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Izmailova E, Bertley FM, Huang Q, et al. (2003). "HIV-1 Tat reprograms immature dendritic cells to express chemoattractants for activated T cells and macrophages". Nat. Med. 9 (2): 191–7. doi:10.1038/nm822. PMID 12539042. S2CID 26145639.
Cui YP, Wang JB, Zhang XY, et al. (2003). "Using yeast two-hybrid system to identify ECRG2 associated proteins and their possible interactions with ECRG2 gene". World J. Gastroenterol. 9 (9): 1892–6. doi:10.3748/wjg.v9.i9.1892. PMC 4656638. PMID 12970870.
Kroczynska B, Evangelista CM, Samant SS, et al. (2004). "The SANT2 Domain of the Murine Tumor Cell DnaJ-like Protein 1 Human Homologue Interacts with α1-Antichymotrypsin and Kinetically Interferes with Its Serpin Inhibitory Activity". J. Biol. Chem. 279 (12): 11432–43. doi:10.1074/jbc.M310903200. PMC 1553221. PMID 14668352.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Sun NN, Fastje CD, Wong SS, et al. (2005). "Dose-dependent transcriptome changes by metal ores on a human acute lymphoblastic leukemia cell line". Toxicology and Industrial Health. 19 (7–10): 157–63. doi:10.1191/0748233703th185oa. PMID 15747776. S2CID 14394243.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000205358 – Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid2286373-3] West AK, Stallings R, Hildebrand CE, Chiu R, Karin M, Richards RI (Mar 1991). "Human metallothionein genes: structure of the functional locus at 16q13". Genomics. 8 (3): 513–8. doi:10.1016/0888-7543(90)90038-V. PMID 2286373.

[pmid8049263-4] Stennard FA, Holloway AF, Hamilton J, West AK (Sep 1994). "Characterisation of six additional human metallothionein genes". Biochim Biophys Acta. 1218 (3): 357–65. doi:10.1016/0167-4781(94)90189-9. PMID 8049263.

[entrez-5] "Entrez Gene: MT1H metallothionein 1H".

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[2]

[3]

[4]

[5]

References

Further reading