MRPS18B

MRPS18B
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3J9M
Identifiers
Aliases	MRPS18B, C6orf14, HSPC183, HumanS18a, MRP-S18-2, MRPS18-2, PTD017, S18amt, mitochondrial ribosomal protein S18B
External IDs	OMIM: 611982; MGI: 1914223; HomoloGene: 32205; GeneCards: MRPS18B; OMA:MRPS18B - orthologs
Gene location (Human) Chr. Chromosome 6 (human) Band 6p21.33 Start 30,617,840 bp End 30,626,395 bp
Gene location (Mouse) Chr. Chromosome 17 (mouse) Band 17|17 B1 Start 36,221,271 bp End 36,227,281 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in gastrocnemius muscle muscle of thigh skeletal muscle tissue left ventricle apex of heart islet of Langerhans human kidney rectum right adrenal gland body of pancreas Top expressed in morula blastocyst embryo epiblast embryo proximal tubule adrenal gland white adipose tissue muscle of thigh placenta More reference expression data BioGPS More reference expression data
Gene ontology Molecular function structural constituent of ribosome protein binding Cellular component cell junction ribosome nucleoplasm intracellular anatomical structure mitochondrial inner membrane mitochondrial small ribosomal subunit mitochondrion Biological process mitochondrial translational elongation protein biosynthesis mitochondrial translational termination mitochondrial translation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 28973 66973 Ensembl ENSG00000229861 ENSG00000226111 ENSG00000204568 ENSG00000203624 ENSG00000227420 ENSG00000233813 ENSG00000223775 ENSMUSG00000024436 UniProt Q9Y676 Q99N84 RefSeq (mRNA) NM_014046 NM_025878 NM_001347380 NM_001361453 NM_001361454 NM_001361455 RefSeq (protein) NP_054765 NP_001334309 NP_080154 NP_001348382 NP_001348383 NP_001348384 Location (UCSC) Chr 6: 30.62 – 30.63 Mb Chr 17: 36.22 – 36.23 Mb PubMed search
Wikidata
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28S ribosomal protein S18b, mitochondrial is a protein that in humans is encoded by the MRPS18B gene.

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed.

Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that belongs to the ribosomal protein S18P family. The encoded protein is one of three that has significant sequence similarity to bacterial S18 proteins. The primary sequences of the three human mitochondrial S18 proteins are no more closely related to each other than they are to the prokaryotic S18 proteins. Pseudogenes corresponding to this gene are found on chromosomes 1q and 2q.

Further reading

• Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
• Shiina T, Ota M, Shimizu S, et al. (2006). "Rapid evolution of major histocompatibility complex class I genes in primates generates new disease alleles in humans via hitchhiking diversity". Genetics. 173 (3): 1555–70. doi:10.1534/genetics.106.057034. PMC 1526686. PMID 16702430.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Zhang Z, Gerstein M (2003). "Identification and characterization of over 100 mitochondrial ribosomal protein pseudogenes in the human genome". Genomics. 81 (5): 468–80. doi:10.1016/S0888-7543(03)00004-1. PMID 12706105.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Suzuki T, Terasaki M, Takemoto-Hori C, et al. (2001). "Proteomic analysis of the mammalian mitochondrial ribosome. Identification of protein components in the 28 S small subunit". J. Biol. Chem. 276 (35): 33181–95. doi:10.1074/jbc.M103236200. PMID 11402041.
• Zhang QH, Ye M, Wu XY, et al. (2001). "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells". Genome Res. 10 (10): 1546–60. doi:10.1101/gr.140200. PMC 310934. PMID 11042152.