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MRPL55

From Wikipedia, the free encyclopedia
MRPL55
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesMRPL55, AAVG5835, L55nt, MRP-L55, PRO19675, mitochondrial ribosomal protein L55
External IDsOMIM: 611859; MGI: 1914462; HomoloGene: 12098; GeneCards: MRPL55; OMA:MRPL55 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)
RefSeq (protein)
Location (UCSC)Chr 1: 228.11 – 228.11 MbChr 11: 59.09 – 59.1 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

39S ribosomal protein L55, mitochondrial is a protein that in humans is encoded by the MRPL55 gene.[5]

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. Multiple transcript variants encoding two different isoforms were identified through sequence analysis.[5]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000162910Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000036860Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b "Entrez Gene: MRPL55 mitochondrial ribosomal protein L55".

Further reading

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