MPP2

MPP2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2E7K
Identifiers
Aliases	MPP2, DLG2, membrane palmitoylated protein 2, MAGUK p55 scaffold protein 2
External IDs	OMIM: 600723; MGI: 1858257; HomoloGene: 3920; GeneCards: MPP2; OMA:MPP2 - orthologs
Gene location (Human) Chr. Chromosome 17 (human) Band 17q21.31 Start 43,875,357 bp End 43,909,711 bp
Gene location (Mouse) Chr. Chromosome 11 (mouse) Band 11 D|11 65.48 cM Start 101,947,841 bp End 101,979,341 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in C1 segment prefrontal cortex right hemisphere of cerebellum right frontal lobe hypothalamus Brodmann area 9 cingulate gyrus anterior cingulate cortex amygdala substantia nigra Top expressed in dentate gyrus of hippocampal formation granule cell primary visual cortex subiculum superior frontal gyrus piriform cortex dorsomedial hypothalamic nucleus neural layer of retina superior colliculus primary motor cortex anterior amygdaloid area More reference expression data BioGPS More reference expression data
Gene ontology Molecular function guanylate kinase activity protein binding Cellular component integral component of plasma membrane postsynaptic density dendrite membrane dendritic spine dendritic shaft cytoplasm cytoskeleton plasma membrane membrane dendrite dendritic spine membrane cell projection Biological process signal transduction GMP metabolic process GDP metabolic process protein homooligomerization excitatory postsynaptic potential long-term potentiation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 4355 50997 Ensembl ENSG00000108852 ENSMUSG00000017314 UniProt Q14168 Q9WV34 RefSeq (mRNA) NM_001278370 NM_001278371 NM_001278372 NM_001278373 NM_001278374 NM_001278375 NM_001278376 NM_001278381 NM_005374 NM_016695 NM_001356324 RefSeq (protein) NP_001265299 NP_001265300 NP_001265301 NP_001265302 NP_001265303 NP_001265304 NP_001265305 NP_001265310 NP_005365 NP_057904 NP_001343253 Location (UCSC) Chr 17: 43.88 – 43.91 Mb Chr 11: 101.95 – 101.98 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

MAGUK p55 subfamily member 2 is a protein that in humans is encoded by the MPP2 gene.

Palmitoylated membrane protein 2 is a member of a family of membrane-associated proteins termed MAGUKs (membrane-associated guanylate kinase homologs). MAGUKs interact with the cytoskeleton and regulate cell proliferation, signaling pathways, and intracellular junctions. Palmitoylated membrane protein 2 contains a conserved sequence, called the SH3 (src homology 3) motif, found in several other proteins that associate with the cytoskeleton and are suspected to play important roles in signal transduction.

Further reading

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Smith SA, Holik P, Stevens J, et al. (1997). "Isolation of a gene (DLG3) encoding a second member of the discs-large family on chromosome 17q12-q21". Genomics. 31 (2): 145–50. doi:10.1006/geno.1996.0025. PMID 8824795.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Shin BK, Wang H, Yim AM, et al. (2003). "Global profiling of the cell surface proteome of cancer cells uncovers an abundance of proteins with chaperone function". J. Biol. Chem. 278 (9): 7607–16. doi:10.1074/jbc.M210455200. PMID 12493773.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Wierstra I, Alves J (2006). "Despite its strong transactivation domain, transcription factor FOXM1c is kept almost inactive by two different inhibitory domains". Biol. Chem. 387 (7): 963–76. doi:10.1515/BC.2006.120. PMID 16913846. S2CID 25571232.