MED11

MED11
Identifiers
Aliases	MED11, HSPC296, mediator complex subunit 11
External IDs	OMIM: 612383; MGI: 1913422; HomoloGene: 32630; GeneCards: MED11; OMA:MED11 - orthologs
Gene location (Human)
Chr.	Chromosome 17 (human)
End	4,733,608 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	70,344,553 bp
RNA expression pattern
	Top expressed in
	right adrenal gland; ; right adrenal cortex; ; left adrenal gland; ; left adrenal cortex; ; skin of arm; ; granulocyte; ; apex of heart; ; myocardium of left ventricle; ; gonad; ; cardiac muscle tissue of right atrium;
	Top expressed in
	internal carotid artery; ; external carotid artery; ; granulocyte; ; yolk sac; ; molar; ; epiblast; ; mesenteric lymph nodes; ; paraventricular nucleus of hypothalamus; ; embryo; ; medial vestibular nucleus;
	More reference expression data
	n/a
Gene ontology
Molecular function	transcription coregulator activity; protein binding; ubiquitin protein ligase activity;
Cellular component	mediator complex; nucleus; ubiquitin ligase complex;
Biological process	regulation of transcription by RNA polymerase II; regulation of transcription, DNA-templated; protein ubiquitination; transcription, DNA-templated;
	Sources:Amigo / QuickGO
Orthologs
	400569
	66172
	ENSG00000161920
	ENSMUSG00000018923
	Q9P086
	Q9D8C6
	NM_001305000; NM_001001683
	NM_025397
	NP_001001683; NP_001291929
	NP_079673
	Wikidata
View/Edit Human	View/Edit Mouse

Mediator complex subunit 11 (Med11) is a protein that in humans is encoded by the MED11 gene.^[5]

Function

Med11 is a component of the Mediator complex, which is a coactivator for DNA-binding factors that activate transcription via RNA polymerase II.^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000161920 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000018923 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: Mediator complex subunit 11".
^ Sato S, Tomomori-Sato C, Banks CA, Sorokina I, Parmely TJ, Kong SE, et al. (April 2003). "Identification of mammalian Mediator subunits with similarities to yeast Mediator subunits Srb5, Srb6, Med11, and Rox3". The Journal of Biological Chemistry. 278 (17). American Society for Biochemistry & Molecular Biology (ASBMB): 15123–7. doi:10.1074/jbc.c300054200. PMID 12584197.

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