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Mammalian protein found in Homo sapiens
Matrin-3 is a protein that in humans is encoded by the MATR3 gene .[ 3] [ 4]
The protein encoded by this gene is localized in the nuclear matrix . It may play a role in transcription or may interact with other nuclear matrix proteins to form the internal fibrogranular network. Two transcript variants encoding the same protein have been identified for this gene.[ 4]
Mutations in the Matrin 3 gene are associated with familial amyotrophic lateral sclerosis .[ 5]
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